Evidence map›Paper›PMID 41403697›Full record

ArticleFrontiers in cell and developmental biology2025

Green-synthesized silver nanoparticles from edible plant extracts ameliorate cadmium chloride-induced hepatorenal and testicular toxicity in rats.

Akram Abu-Okail, Abdullah S M Aljohani, Ayman M Mousa, Heba A S El-Nashar, Mohamed El-Shazly, Ramy K A Sayed, Waleed Al Abdulmonem, Mohamed Farghali, Heba F Kamaly, Ibrahim M El-Ashmawy and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Akram Abu-OkailDepartment of Pathology and Laboratory Diagnosis, College of Veterinary Medicine, Qassim University, Buraydah, Saudi Arabia.
Abdullah S M AljohaniDepartment of Medical Biosciences, College of Veterinary Medicine, Qassim University, Buraydah, Saudi Arabia.
Ayman M MousaDepartment of Basic Health Sciences, College of Applied Medical Sciences, Qassim University, Buraidah, Saudi Arabia.
Heba A S El-NasharDepartment of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Mohamed El-ShazlyDepartment of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Ramy K A SayedDepartment of Anatomy and Embryology, Faculty of Veterinary Medicine, Sohag University, Sohag, Egypt.
Waleed Al AbdulmonemDepartment of Pathology, College of Medicine, Qassim University, Buraydah, Saudi Arabia.
Mohamed FarghaliDepartment of Animal and Poultry Hygiene and Environmental Sanitation, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt.
Heba F KamalyDepartment of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt.
Ibrahim M El-AshmawyDepartment of Medical Biosciences, College of Veterinary Medicine, Qassim University, Buraydah, Saudi Arabia.
Ahmed A H AbdellatifDepartment of Pharmaceutics, College of Pharmacy, Qassim University, Buraydah, Saudi Arabia.
Nashwa HamadDepartment of Pathology, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Cadmium (Cd) is widely known as an environmental toxicant, ranked as the seventh most toxic heavy metal. Exposure to cadmium through inhalation and ingestion can lead to serious health issues, including liver damage, kidney degeneration, testicular problems, and blood disorders in both humans and animals. Objective: This study aimed to evaluate the protective effects of biosynthesized silver nanoparticles (AgNPs) against cadmium chloride-induced hepatic, renal, and reproductive toxicity in male rats. Methods: AgNPs were synthesized via chemical reduction in silver nitrate using a combination of three plant extracts, namely, Results: Synthesized AgNPs exhibited spherical morphology, with an average nanosize distribution of 5.28-21.47 nm. Cadmium chloride exposure significantly elevated liver enzymes, lipid markers, urea, creatinine, and MDA while decreasing testicular hormone levels (testosterone and luteinizing hormone), indicating hepato-renal and testicular damage, alongside histopathological damage in all examined organs. Co-administration of AgNPs markedly ameliorated these biochemical alterations, improving liver and kidney function, restoring total antioxidant capacity, and normalizing lipid, protein, and testicular hormone profiles. Histopathological results revealed that treatment with AgNPs restored the angiopathic, degenerative, and necrotic changes prompted by cadmium chloride administration. Conclusion: AgNPs biosynthesized from combined extracts of

Indexed as

antioxidantcadmiumgreen-silver nanoparticleskidneylivertestes

Identifiers

PMID41403697
PMCPMC12702896

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.