ArticleArchives of medical science : AMS2025
Whole-body water mass and osteoarthritis: a Mendelian randomization study.
Article in Archives of medical science : AMS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Introduction: This study aimed to elucidate the potential impact of whole-body water mass on osteoarthritis at the genetic prediction level through a two-sample Mendelian randomization (MR) analysis. Material and methods: Using summary data from genome-wide association studies, we obtained information on whole-body water mass and various forms of osteoarthritis, including knee and hip osteoarthritis, knee osteoarthritis, and hip osteoarthritis from a large-scale genome-wide association study. MR analysis used inverse variance weighting, weighted median, MR-Egger, simple mode, and weighted estimation. Sensitivity analyses, including the MR-Egger method, MR-PRESSO, Cochran's Q-test, and leave-one-out assessment, were performed to assess the reliability of the results. Results: In the inverse variance weighting model, increased genetic susceptibility to whole-body water mass was significantly associated with knee and hip osteoarthritis, knee osteoarthritis, and hip osteoarthritis (OR = 1.45, 95% CI: 1.27-1.65, Conclusions: The MR analysis suggests a positive correlation between whole-body water mass and risk of osteoarthritis.
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