ReviewArchives of medical science : AMS2025
Efficacy and safety of proton pump inhibitors for diabetes mellitus in patients with gastroesophageal reflux disease: a meta-analysis.
Review in Archives of medical science : AMS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Introduction: Gastroesophageal reflux disease (GERD) is prevalent in patients with type 2 diabetes mellitus (T2DM). The use of proton pump inhibitors (PPIs) is recognized as an effective method to reduce gastric acid secretion in patients with GERD. Nevertheless, whether PPIs are effective or safe for the treatment of T2DM complicated by GERD remains unknown. Material and methods: To assess the efficacy and safety of PPIs in the management of T2DM complicated with GERD, databases including Web of Science, Cochrane Library, PubMed, and Embase were comprehensively searched for randomized controlled trials (RCTs) focusing on the treatment of T2DM complicated with GERD published before December 2023. Following data extraction and quality assessment, outcomes, including endoscopic efficiency, fasting blood glucose (FBG), symptom relief rates, levels of glycosylated hemoglobin A Results: The results suggest that the PPI group exhibited a higher efficacy rate compared to the control group in endoscopic efficiency (69.32% vs. 5.45%, OR = 40.50, 95% CI: 18.77-87.39) and symptom relief rates (92.94% vs. 54.65%, OR = 6.45, 95% CI: 3.41-12.20). Furthermore, PPI treatment was associated with a significant reduction in HbA Conclusions: PPIs can effectively improve the glycemic control of patients with T2DM complicated with GERD.
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