ArticleArchives of medical science : AMS2025
Fresh autologous blood transfusion reverses erythrocyte damage by reducing oxidative stress via promoting mitochondrial metabolism and M2 macrophage polarization.
Article in Archives of medical science : AMS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
Introduction: Systemic inflammatory and immunosuppressive incidents constitute a significant hallmark of the adverse effects of RBC transfusion on red blood cells. These adverse side effects are seemingly associated with old blood transfusions; therefore, we aimed to investigate the underlying mechanism of fresh autologous blood transfusion (fABT) and its subsequent effect in diabetic mice. Material and methods: In the present Results: The results showed that fresh autologous blood transfusion markedly reduced M2 macrophage polarization, enhanced hepatic mitochondrial metabolism, reduced hepatic oxidative stress, and promoted the oxygen-carrying capacity of red blood cells while reducing osmotic fragility and oxygen consumption. Moreover, we found that fABT promoted the IGF2/PI3K signaling pathway, indicating the vital necessity of providing fresh autologous blood transfusion during therapy or surgery. Conclusions: Our results are the first to highlight the underlying mechanism by which fABT modulates physiological patterns in a diabetic animal model, and provide a sound basis for utilizing fABT in clinical applications.
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