ArticleFrontiers in physiology2025
Impact of individualized tidal volume strategies on intraoperative lung protection and inflammatory markers in laparoscopic cholecystectomy: a randomized controlled trial.
Article in Frontiers in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Early Pulmonary Stress During Intra-Abdominal Hypertension and Hypervolemia: Surfactant Protein A1 and Multi-Compartment Biomarker Responses in Rats.Life (Basel, Switzerland) · 2026Article
- Comparison of systemic vascular resistance index-guided versus conventional fluid management on airway pressure, oxygenation and postoperative recovery in patients undergoing one-lung ventilation for thoracic surgery.American journal of translational research · 2026Article
- Mechanisms and clinical research progress of IL-6-mediated crosstalk between the alveolar microenvironment and the immune system in patients with severe pneumonia undergoing mechanical ventilation.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: The aim of this study is to evaluate the impact of individualized tidal volume settings, as compared to conventional settings on lung injury in patients undergoing laparoscopic cholecystectomy under mechanical ventilation. Methods: A total of 40 patients scheduled for elective laparoscopic cholecystectomy at the Affiliated Hospital of Inner Mongolia Medical University between August 2024 and January 2025 were enrolled in this randomized study. Participants were randomly assigned using a random number table to either the control group (Group C, n = 20) or the experimental group (Group T, n = 20), based on the method of tidal volume adjustment. Group C received a conventional tidal volume of 8 mL/kg. In Group T, resting tidal volume was measured preoperatively and used to individualize the mechanical ventilation settings. Serum levels of HTI56, surfactant protein A (SP-A), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) were measured at T1 (prior to anesthesia) and T4 (6 h postoperatively). Mean arterial pressure (MAP) and heart rate were recorded at four time points: T1 (baseline), T2 (20 min post-intubation), T3 (40 min post-intubation), and T4 (6 h postoperatively). Airway parameters including peak airway pressure (Ppeak), plateau pressure (Pplat), and mean airway pressure (Pmean) were documented at T2 and T3. Results: The average delivered tidal volume in Group T was lower than that in Group C (6.2 ± 0.5 mL/kg vs. 8.0 ± 0.3 mL/kg), indicating a statistically significant difference ( Conclusion: Individualized tidal volume settings were associated with significantly lower postoperative elevations of IL-6, TNF-α, HTI56, and SP-A compared to conventional settings. These findings suggest that tailoring tidal volume based on resting respiratory parameters may help mitigate lung capillary barrier injury by attenuating the inflammatory response, thereby enhancing pulmonary protection during mechanical ventilation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.