ArticleFrontiers in pharmacology2025
Improved exposure of curcumin-loaded nanocapsules: drug quantification in LPS-induced
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Curcumin (CUR) has broad pharmacological potential; however, its clinical efficacy is hindered by low aqueous solubility, extensive presystemic metabolism, and poor oral bioavailability. Nanoencapsulation strategies have been proposed to overcome these limitations. Methods: We evaluated the exposure of poly(ε-caprolactone) nanocapsules coated with polysorbate 80 containing CUR (NC-CUR) using a validated bioanalytical approach capable of quantifying CUR in whole-body homogenates of Drosophila melanogaster and in rat plasma. Healthy and LPS-challenged flies were chronically treated with CUR or NC-CUR (37 or 110 ng/mL) for 10 days through dietary exposure. Male Wistar rats received a single intravenous (2 mg/kg) or oral (6 mg/kg) dose of CUR or NC-CUR to characterize systemic pharmacokinetics. Results: In vitro release followed a biexponential profile, with NC-CUR showing significantly prolonged release compared to free CUR (t Discussion: Nanoencapsulation significantly enhanced CUR exposure in both invertebrate and mammalian systems. This cross-species analytical strategy supports
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