ArticleERJ open research2025
Patient perspectives and priorities in pleural infection: results of the MIST-3 feasibility trial qualitative substudy.
Article in ERJ open research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
9 authors.
Funding
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Abstract
The question addressed by the study: The optimal treatment for pleural infection is yet to be determined and recruitment to trials can be challenging. Research into patient priorities in pleural infection is lacking. This qualitative study aimed to help us understand the patient perspective regarding priorities of care, to identify patient-centred study outcomes, and to explore the understanding of the risks and benefits of randomisation to different pleural interventions. Methods: A prospective, multicentre, qualitative study using a semi-structured interview methodology explored key themes addressing the experiences of participation in a pleural infection randomised controlled trial (RCT) of combination intrapleural enzyme therapy Results: Thematic analysis identified five main themes: emotions, level of explanation and understanding, reaction to randomisation, influences on physical wellbeing, and overall experience. Pain was a significant feature due to both the infection and interventions. The overriding emotions described by patients were fear and anxiety. Participants demonstrated high levels of support for randomised allocation to intervention. The answer to the question: A pleural infection patient-reported outcome measure should be developed to assess pain, fatigue, anxiety and breathlessness, so that valid health-related quality of life data can be captured. Pain is an undertreated symptom of pleural infection and should be incorporated into treatment protocols. There was no clear patient preference between the interventions, and a surgical
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