ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2025
Association of Fasting C-Peptide to High Density Lipoprotein Cholesterol Ratio with Non-Alcoholic Fatty Liver Disease in Chinese Type 2 Diabetes Mellitus Patients: A Cross-Sectional Study.
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Comment On: Association of Fasting C-Peptide to High Density Lipoprotein Cholesterol Ratio with Non-Alcoholic Fatty Liver Disease in Chinese Type 2 Diabetes Mellitus Patients: A Cross-Sectional Study [Response to Letter].Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Comment on: "Association of Fasting C-Peptide to High Density Lipoprotein Cholesterol Ratio with Non-Alcoholic Fatty Liver Disease in Chinese Type 2 Diabetes Mellitus Patients: A Cross-Sectional Study" [Letter].Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To investigate fasting C-peptide to high-density lipoprotein cholesterol ratio (FHR) as a predictor for non-alcoholic fatty liver disease (NAFLD) in Chinese adults with type 2 diabetes mellitus (T2DM). Methods: This study enrolled 718 participants with T2DM from Shenzhen People's Hospital, China. Participants were stratified by FCP/HDL-C ratio (FHR) quartiles. Multiple linear regression assessed the association between FHR and NAFLD. A generalized additive model (GAM) tested for nonlinearity. Subgroup analyses evaluated result robustness. The area under the curve (AUC) evaluated the performance of the FHR model for NAFLD occurrence. Results: After adjusting for relevant variables, FHR was positively correlated with NAFLD (OR = 1.30, 95% CI (1.15, 1.48)). FHR demonstrated a nonlinear association with NAFLD, characterized by a threshold value of 1.23. The effect sizes and confidence intervals on the left and right sides of the inflection point were 3.07 (1.51, 6.24) and 1.20 (1.05, 1.37), respectively. Subgroup analysis showed a stronger correlation could be detected in patients with systolic blood pressure (SBP) <140 mmHg, alanine transaminase (ALT) > 40U/L, fasting blood glucose (FBG) ⩽7 mmol/L, urinary albumin to creatinine ratio (UACR) ⩽30mg/g, triglyceride (TG) ⩽1.7 mmol/L and the patients with drinking history. The FHR ratio model exhibited better discriminative ability in NAFLD (AUC = 0.697) compared to individual FCP (AUC = 0.649) or HDL-C (AUC = 0.635) alone. Conclusion: The association between FHR and NAFLD was nonlinear, with a positive relationship observed when FHR exceeded the threshold of 1.23.
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