ArticleInternational medical case reports journal2025
Linezolid Associated Asymptomatic Hypoglycemia in a Patient with Advanced Gynecologic Cancer: A Case Report and Literature Review.
Article in International medical case reports journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Hypoglycemia is a rare but documented adverse effect of linezolid. We report a 72-year-old patient with late-stage gynecologic cancer and abdominal MRSA peritonitis, who developed persistent asymptomatic hypoglycemia after starting linezolid. The patient had type 2 diabetes on metformin-glibenclamide. Fasting blood glucose dropped to 2.08 mmol/L (reference: 3.9-6.1 mmol/L) 1 day post-linezolid initiation; hypoglycemia persisted despite stopping oral hypoglycemics and administering dextrose, but normalized within 24 hours after linezolid discontinuation (replaced with tigecycline). Naranjo ADR Scale scoring (7 points) confirmed a "probable" causal link. We present dynamic glucose trends (reinforcing causality) and review linezolid-associated hypoglycemia literature. This case highlights the need for glucose monitoring in linezolid-treated patients, especially at high risks, even without diabetes or symptoms.
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