ArticleHaemophilia : the official journal of the World Federation of Hemophilia
Acceptability and Determinants for Implementation of the EnzySystem, a Novel Near-Patient Testing Platform for Haemophilia A.
Article in Haemophilia : the official journal of the World Federation of Hemophilia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionCoagulation testing in haemophilia A is limited by the scarcity of testing facilities capable of performing relevant assays. This issue incentivized the development of the EnzySystem for haemophilia A, a near-patient testing platform aimed to measure Factor VIII activity and thrombin generation simultaneously within 1 h from 100 µL of whole blood. Involving end-users throughout the development ensures innovations are well-suited to meet real-world clinical needs.
aimTo determine EnzySystem's acceptance, envisioned use scenarios and determinants for implementation according to healthcare providers (HCPs) and persons with haemophilia A and caregivers (PwHA/C).
methodsA single-centre, cross-sectional mixed methods study was performed involving two participant groups. The first involved 36 PwHA/C. The second group comprised five advanced practice providers, eight nurses, four pharmacists and five haematologists, all involved in haemophilia A care. The participants' attitudes and preferences toward the EnzySystem for haemophilia A were assessed through questionnaires and focus groups.
resultsAcceptability was high for both groups. The platform was considered suitable for use in various scenarios, but self-testing at home was prioritized by PwHA/C. HCPs placed equal emphasis on near-patient testing in clinic to address issues with current test accessibility and turnaround time. For all potential use scenarios, demonstrating assay accuracy was a non-negotiable prerequisite. The turnaround time and accessibility were identified as other key attributes by both groups.
conclusionThe results of this study support the further development of the EnzySystem for haemophilia A and highlight barriers that should be addressed to facilitate implementation.
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