Evidence map›Paper›PMID 41403303›Full record

ArticleFuture science OA2026

Clinicohistopathological characteristics of renal cell carcinoma in Jordan.

Mohammad Al-Zubi, Rana Haddad, Ammar Badr, Hayat Al Bibi, Saif Azzam, Mohammad Araydah, Ahmed Al Sharie, Karis Khattab, Hussein Qasim, Sarah Al Sharie

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Article in Future science OA, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Mohammad Al-ZubiDepartment of General Surgery and Anesthesia, Faculty of Medicine, Yarmouk University, Irbid, Jordan.
Rana HaddadFaculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
Ammar BadrFaculty of Medicine, Yarmouk University, Irbid, Jordan.
Hayat Al BibiFaculty of Medicine, Yarmouk University, Irbid, Jordan.
Saif AzzamFaculty of Medicine, Yarmouk University, Irbid, Jordan.
Mohammad AraydahDepartment of Internal Medicine, Istishari Hospital, Amman, Jordan.
Ahmed Al SharieDepartment of Internal Medicine, Southeast Health Hospital, Dothan, AL, USA.
Karis KhattabFaculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
Hussein QasimDepartment of Pathology and Laboratory Medicine, Jordan University of Science and Technology, Irbid, Jordan.
Sarah Al SharieLaboratory of Science and Translation in Critical Illness, Vanderbilt University Medical Center, Nashville, TN, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRenal cell carcinoma (RCC) is the most common adult kidney malignancy, yet regional data from the Middle East are limited. This study characterized the clinicopathological, immunohistochemical, and survival features of RCC in a Jordanian cohort.

methodsA retrospective analysis of 295 RCC cases (2020-2024) from Yarmouk University affiliated hospitals was conducted. Clinical and pathological parameters, immunohistochemical markers, and survival were analyzed using Kaplan-Meier and log-rank tests.

resultsClear-cell RCC was the predominant subtype (72.2%), followed by papillary (10.5%), chromophobe (9.1%), and others (8.1%). The mean age was 62.1 years, with male predominance (66.4%). Clear-cell RCC showed higher rates of high-grade histology, sarcomatoid and rhabdoid differentiation, capsule invasion, renal vein involvement, and metastasis (p < 0.05), while chromophobe RCC was indolent with no metastases. CK7, Hale's iron, and c-kit characterized chromophobe RCC, vimentin was typical of clear-cell, and AMACR of papillary RCC. Survival was significantly worse with older age, higher T stage, sarcomatoid features, and higher ISUP grade, while nephrectomy type had no effect.

conclusionsClear-cell RCC demonstrated aggressive pathology, whereas chromophobe RCC was indolent. Age, subtype, stage, and sarcomatoid features were key prognostic factors, highlighting the need for early detection and expanded nephron-sparing surgery in the region.

Indexed as

chromophobe RCCclear-cell RCChistopathologyimmunohistochemistrypapillary RCCRenal cell carcinomarhabdoid featuressarcomatoid differentiation

Identifiers

PMID41403303
PMCPMC12716033

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