ArticleThe British journal of nutrition2026
Purified diet reduces intestinal IgA and alters the microbiota accordingly.
Article in The British journal of nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Diet can affect health directly or by altering the gut microbiota; thus, there are strong interrelationships between the gut immune system, gut microbiota and diet. This study examined the effects of ingesting AIN-93M purified diet (PD) on gut immune function and gut microbiota in DO11·10 mice, in which T cell-dependent and T cell-independent (TI) IgA can be analysed separately. Ingestion of the PD for 2 weeks reduced both T cell-dependent and TI secretory IgA in the faeces compared with non-PD, whereas the diet did not affect T cell-dependent and TI serum IgA. Ingestion of the PD had no effect on systemic immune system splenocyte responses. Ingestion of the PD reduced intestinal tissue expression levels of B-cell activating factor and A proliferation-inducing ligand, cytokines involved in TI-IgA production and polymeric Ig receptor, which transports IgA into the intestinal lumen. Co-abundance group (CAG) analysis of the intestinal microbiota was conducted based on correlations between changes in the abundance of bacterial genera, and the correlations between CAG and IgA were determined. The
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