Evidence map›Paper›PMID 41403042›Full record

ArticleInternational journal of dermatology2026

The Effect of Myrtacine and Celastrol-Enriched Extract on Cutibacterium acnes Extracellular Vesicles.

Caroline T Cheung, Céline Mias, Ugo Lancien, Stéphane Corvec, Valérie Mengeaud, Amir Khammari, Hélène Duplan, Brigitte Dréno

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Caroline T CheungNantes University, INSERM, CNRS, Immunology and New Concepts in ImmunoTherapy (INCIT), Nantes, France.ORCID https://orcid.org/0009-0002-7119-4896
Céline MiasPierre Fabre Dermo-Cosmétique et Personal Care, Toulouse, France.ORCID https://orcid.org/0000-0001-8055-8255
Ugo LancienNantes University, CHU Nantes Chirurgie Plastique, Reconstructrice et Esthétique et Centre de Traitement Des Brûlés, Nantes, France.ORCID https://orcid.org/0000-0003-1262-5510
Stéphane CorvecCHU Nantes Bacteriology Department, Nantes University, Nantes, France.ORCID https://orcid.org/0000-0003-3176-8111
Valérie MengeaudMedical Direction, Laboratoires Dermatologiques Ducray, Lavaur, France.ORCID https://orcid.org/0000-0001-8585-3974
Amir KhammariNantes University, INSERM, CNRS, Immunology and New Concepts in ImmunoTherapy (INCIT), Nantes, France.ORCID https://orcid.org/0000-0001-9328-8004
Hélène DuplanPierre Fabre Dermo-Cosmétique et Personal Care, Toulouse, France.ORCID https://orcid.org/0000-0001-9414-8070
Brigitte DrénoNantes University, INSERM, CNRS, Immunology and New Concepts in ImmunoTherapy (INCIT), Nantes, France.ORCID https://orcid.org/0000-0001-5574-5825

Funding

Les Laboratories Pierre Fabre
6 · The paper itself

Abstract

backgroundCommensal bacteria interact with each other and their environment, secreting anti-microbial peptides, bacteriocins, and extracellular vesicles (EVs). Cutibacterium acnes (C. acnes), a commensal bacterium that plays a major role in acne, is classified into different phylotypes (IA

methodsThis study was conducted under preventive and modulating conditions: Myrtacine alone, CEE alone, or in combination were added to the culture medium either prior to (preventive) or after (modulating) incubation with C. acnes IA

resultsPreventive and modulating applications of Myrtacine and CEE significantly reduced expression of the five immune markers induced specifically by EVs from acne-derived C. acnes IA

conclusionOur results show that C. acnes EVs may be a target of Myrtacine and CEE. They can down-modulate the pro-inflammatory activity induced by EVs derived from C. acnes IA

Indexed as

Acne VulgarisAnti-Inflammatory AgentsExtracellular VesiclesPlant ExtractsPropionibacteriaceaePropionibacterium acnesTriterpenesbeta-DefensinsCytokinesHaCaT CellsHumansImmunity, InnateKeratinocytesPentacyclic TriterpenesSkinAnti-Inflammatory Agentsbeta-DefensinscelastrolCytokinesDEFB4A protein, humanPentacyclic TriterpenesPlant ExtractsTriterpenesacneCelastrol‐enriched extractCutibacterium acnesextracellular vesiclesMyrtacine

Identifiers

PMID41403042
PMCPMC13161522

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.