Evidence map›Paper›PMID 41402996›Full record

ReviewNucleus (Austin, Tex.)2026

Mechanotransduction by nuclear envelope tension.

Sriivatsan G Rajan, Pere Roca-Cusachs, Philipp Niethammer

Abstract readReview
In one paragraph

Review in Nucleus (Austin, Tex.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sriivatsan G RajanCell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Pere Roca-CusachsInstitute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Philipp NiethammerCell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Chemical and Physical Mechanisms of Wound DetectionR35GM140883 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI Philipp Michael Niethammer · 2021 to 2026
$3.8M
NCI NIH HHS P30 CA008748NIGMS NIH HHS R35 GM140883
6 · The paper itself

Abstract

Mechanotransduction mediated by the tension in lipid membranes is a well-established paradigm. This has been studied largely in the context of the plasma membrane, but recent work shows that it applies also to endomembranes, and specifically to the nuclear envelope. Here, we review membrane tension-mediated mechanotransduction at the nuclear envelope by focusing on its two best characterized modes of action: the cytosolic phospholipase A2 (cPLA

Indexed as

Mechanotransduction, CellularNuclear EnvelopeAnimalsHumansNuclear PorePhospholipases A2Phospholipases A2Cytosolic phospholipase A2mechanobiologymembranenuclear deformationnuclear envelopenuclear pore complexnuclear transportnucleustensionYAP

Identifiers

PMID41402996
PMCPMC12716060

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.