Evidence map›Paper›PMID 41402965›Full record

Observational studyBreast cancer research : BCR2025

Histologic correlates of background parenchymal uptake on molecular breast imaging.

Lydia Bardwell Speltz, Karthik Ghosh, Daniel W Visscher, Christopher G Scott, Kristin C Cole, Trynda N Kroneman, Robert W Maxwell, Amy Lynn Conners, Katie N Hunt, Deborah J Rhodes and 2 more

2 registry-linked trialsAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Breast cancer research : BCR, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01240278 completednot on this map

Pilot Study to Examine Histological Characteristics of Mammographic Density With Molecular Breast Imaging: Part 1 - Postmenopausal Women

TypeobservationalSponsorMayo ClinicRan2010 to 2022Enrolled25ConditionsDense Breasts, Breast Cancer
NCT01588834 completednot on this map

Pilot Study to Examine Histological Characteristics of Mammographic Density With Molecular Breast Imaging: Part 2 - Premenopausal Women

TypeobservationalSponsorMayo ClinicRan2012 to 2016Enrolled23ConditionsDense Breasts, Breast CancerArmsbreast biopsy
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lydia Bardwell SpeltzDepartment of Radiology, Mayo Clinic, 200 First St. SW, Rochester, MN, 55905, USA.
Karthik GhoshDepartment of Medicine, Mayo Clinic, 200 First St. SW, Rochester, MN, 55905, USA.
Daniel W VisscherDepartment of Laboratory Medicine and Pathology, Mayo Clinic, 200 First St. SW, Rochester, MN, 55905, USA.
Christopher G ScottDepartment of Quantitative Health Sciences, Mayo Clinic, 200 First St. SW, Rochester, MN, 55905, USA.
Kristin C ColeDepartment of Quantitative Health Sciences, Mayo Clinic, 200 First St. SW, Rochester, MN, 55905, USA.
Trynda N KronemanDepartment of Laboratory Medicine and Pathology, Mayo Clinic, 200 First St. SW, Rochester, MN, 55905, USA.
Robert W MaxwellDepartment of Radiology, Mayo Clinic, 4500 San Pablo Rd S, Jacksonville, FL, 32224, USA.
Amy Lynn ConnersDepartment of Radiology, Mayo Clinic, 200 First St. SW, Rochester, MN, 55905, USA.
Katie N HuntDepartment of Radiology, Mayo Clinic, 200 First St. SW, Rochester, MN, 55905, USA.
Deborah J RhodesDepartment of Medicine, Mayo Clinic, 200 First St. SW, Rochester, MN, 55905, USA.
Celine M VachonDepartment of Quantitative Health Sciences, Mayo Clinic, 200 First St. SW, Rochester, MN, 55905, USA.
Carrie B HruskaDepartment of Radiology, Mayo Clinic, 200 First St. SW, Rochester, MN, 55905, USA. hruska.carrie@mayo.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMolecular breast imaging (MBI) has shown utility as a supplement to mammography in women with dense breasts. Background parenchymal uptake (BPU), which describes the level of Tc-99 m sestamibi in fibroglandular tissue on MBI, varies among women with similar density. Higher BPU is associated with greater breast cancer risk. The goal of this work is to investigate the histological correlations of BPU that may explain this association with risk.

methodsIn healthy women with dense tissue on mammography, we prospectively biopsied regions of fibroglandular tissue exhibiting one of the extreme categories of BPU on MBI: either photopenic or marked. Tissue composition of specimens was assessed by measuring area of epithelium, stroma, and fat and counting lobules. Lobular involution status was assessed by an expert pathologist as either none, partial, or complete. Ki-67 index and estrogen receptor-alpha expression were also assessed. Histologic features of photopenic and marked specimens were compared.

resultsBiopsies were performed in 48 women (mean age 54.9 years [SD 11.1 years]), including 20 with marked BPU and 28 with photopenic BPU. Women with marked BPU were younger (mean age 49.9 vs. 58.4 years, p = 0.004), had higher body mass index (p = 0.01), and were more likely premenopausal (p = 0.005). Marked BPU specimens had a higher proportion of epithelium (14.5% vs. 2.2%, p < 0.001), lower stromal content (44.8% vs. 84.2%, p = 0.005), similar fat (18.9% vs. 12.9%, p = 0.41), and greater lobule counts (15.5 vs. 6.3, p < 0.001) compared to photopenic specimens. Complete lobular involution was less frequent in marked tissue than in photopenic tissue (10.5% vs. 76%, p < 0.001). Ki-67 index was higher in marked BPU tissues (5.4% vs. 1.6%, p = 0.006), though the difference was attenuated after adjustment for epithelial area (p = 0.26). Estrogen receptor-alpha expression did not differ between marked and photopenic groups (25.6% vs. 28.4%, p = 0.12).

conclusionsMarked BPU on MBI is associated with greater epithelial content, less lobular involution, and higher proliferative activity-features characteristic of tissue at elevated risk for malignant transformation. These findings suggest that BPU provides functional information beyond mammographic density, supporting its role as an imaging biomarker for breast cancer risk in women with dense breasts.

trial registrationNCT01240278 || 11/15/2010 and NCT01588834 || 05/01/2012.

Indexed as

BreastBreast NeoplasmsMolecular ImagingParenchymal TissueTechnetium Tc 99m SestamibiAdultAgedBiopsyBreast DensityEstrogen Receptor alphaFemaleHumansKi-67 AntigenMammographyMiddle AgedProspective StudiesEstrogen Receptor alphaKi-67 AntigenRadiopharmaceuticalsTechnetium Tc 99m SestamibiBreast cancer riskBreast densityLobular involutionMolecular breast imagingTc-99m sestamibi

Identifiers

PMID41402965
PMCPMC12709754

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.