ArticleCancer & metabolism2025
The role of deoxycholic acid in macrophage polarization and remodeling of the tumor microenvironment during colorectal adenoma-carcinoma transition.
Article in Cancer & metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Metabolic adaptations of the tumor macroenvironment and their role in cancer progression and survivorship.Genes & development · 2026Review
- Development and Internal Validation of a LASSO-Based Prediction Model for Colorectal Adenoma Recurrence After Polypectomy.Cancer management and research · 2026Article
- Multi-omics analyses unveil gut microbiota and metabolites signatures in deoxycholic acid-associated intestinal inflammation.Frontiers in microbiology · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
Abstract
During the progression from colorectal adenoma to colorectal cancer (CRC), the inflammatory state of the tumor microenvironment (TME) evolves in parallel with the epithelial‒mesenchymal transition (EMT) process. Among the key players, macrophages serve as pivotal mediators of inflammation-cancer transformation and are closely associated with these dynamic changes. Deoxycholic acid (DCA), a critical bile acid metabolite involved in CRC development, has been implicated in tumorigenesis; however, its role in macrophage polarization and the adenoma-carcinoma sequence remains unclear. In this study, we analyzed clinical cell types and DCA levels in colorectal adenomas and carcinomas to elucidate the correlation between DCA and macrophages in CRC. Furthermore, we investigated the mechanistic role of DCA in promoting M2-like polarization of tumor-associated macrophages and validated the impact of DCA on the EMT-associated Wnt/β-catenin pathway and inflammation-associated NF-κB signaling pathway in CRC model mice. Our findings may provide novel strategies for prognostic biomarkers and precise bile acid metabolism-based interventions in CRC.
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Registered trials
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