ArticleThe journal of headache and pain2025
5.0 T MRI reveals characteristic alterations in visual and somatomotor networks associated with migraine chronification: a single-center prospective cohort study.
Article in The journal of headache and pain, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Temporal neural dynamics patterns in episodic and chronic migraine: a magnetoencephalography study.The journal of headache and pain · 2026Article
- Comparative evaluation of dynamic susceptibility contrast MRI techniques for brain imaging at 3T and 5T magnetic field strengths.Frontiers in human neuroscience · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
BACKGROUND AND
objectivesMigraine is increasingly acknowledged as a disorder of large-scale brain network hierarchy rather than a merely focal dysfunction. However, the neural substrates driving the transition from episodic migraine (EM) to chronic migraine (CM)-a key pathological process in migraine chronification, remain poorly delineated.
methodsUsing 5.0 T MRI, we examined 122 participants (30 healthy controls [HC], 66 EM, and 16 CM). Morphometric INverse Divergence (MIND)-based structural similarity networks and resting-state functional connectivity (FC) matrices were constructed from 3D T1 and rs-fMRI data parcellated with the Schaefer-400 atlas. Diffusion map embedding was applied to derive low-dimensional gradients indexing macroscale cortical hierarchy. Group differences in the principal gradient (G1) were assessed using one-way ANOVA with FDR-corrected post hoc tests. Partial Spearman correlations were used to link regional G1 values with attack frequency, disease duration, and anxiety (HAMA), depression (HAMD), and sleep quality (PSQI) scores.
resultsBoth MIND- and FC-derived gradients revealed a progressive flattening of the G1 along the HC-EM-CM continuum. These alterations were most prominent in the visual and somatomotor networks. Across the top overlapping regions, lower G1 values, reflecting diminished hierarchical segregation, were consistently associated with higher HAMA and HAMD scores and poorer sleep quality on the PSQI after FDR correction, particularly within visual–somatomotor network.
conclusions5.0 T MRI demonstrated a consistent, cross-modal disruption of the cortical hierarchy linked to migraine chronification, emphasizing the reduced hierarchical differentiation of visual-sensorimotor integration and its coupling with affective and sleep dysfunction. Gradient-based metrics may provide promising imaging markers for tracking disease progression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.