Evidence map›Paper›PMID 41402696›Full record

ArticleFrontiers of medicine2025

Macrophage-derived semaphorin 7A drives atherosclerosis via the integrin β1/JNK/MSR1 axis.

Fengchan Li, Haofu Ni, Fan Tang, Jiaxin Lyu, Lili Wu, Lijie Ren, Qiongyu Lu, Shouming Zhao, Chaojun Tang, Li Zhu

Abstract read
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In one paragraph

Article in Frontiers of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Fengchan Li *Cyrus Tang Medical Institute, Soochow University, Suzhou, 215123, China.
Haofu Ni *Cyrus Tang Medical Institute, Soochow University, Suzhou, 215123, China.
Fan Tang *Cyrus Tang Medical Institute, Soochow University, Suzhou, 215123, China.
Jiaxin LyuCyrus Tang Medical Institute, Soochow University, Suzhou, 215123, China.
Lili WuSuzhou Ninth Hospital Affiliated to Soochow University, Soochow University, Suzhou, 215200, China.
Lijie RenCyrus Tang Medical Institute, Soochow University, Suzhou, 215123, China.
Qiongyu LuCyrus Tang Medical Institute, Soochow University, Suzhou, 215123, China.
Shouming ZhaoDepartment of Cardiology, the First People's Hospital of Taicang, Taicang Affiliated Hospital of Soochow University, Soochow University, Suzhou, 215400, China.
Chaojun TangCyrus Tang Medical Institute, Soochow University, Suzhou, 215123, China. zjtang@suda.edu.cn.
Li ZhuSuzhou Ninth Hospital Affiliated to Soochow University, Soochow University, Suzhou, 215200, China. zl15195682930@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atherosclerosis is a chronic inflammatory disease driven by pathological processes such as macrophage foam cell formation. Semaphorin 7A (SEMA7A) is an immunoregulatory signaling molecule known to modulate immune responses and cellular adhesion. However, the contribution of macrophage-derived SEMA7A to atherogenesis has yet to be fully elucidated. In this study, we analyzed gene expression profiles of human mononuclear cells from the Gene Expression Omnibus (GEO) database and revealed highly expressed SEMA7A and its receptor integrin β1 in macrophages. The upregulation of SEMA7A and integrin β1 was also observed during the differentiation of THP-1 monocytes into macrophages. Mice with macrophage-specific deletion of Sema7a showed a 57.2% reduction in atherosclerotic lesion size and improved plaque stability in atherosclerosis mouse model compared to control mice. Mechanistically, macrophage SEMA7A promoted the expression of macrophage scavenger receptor 1 (MSR1) and lipid uptake mediated by integrin β1 and downstream JNK signaling pathway in macrophages. Notably, pharmacological inhibition of integrin β1 with integrin receptor antagonist GLPG0187 effectively suppressed atherosclerosis progression. These findings identify macrophage-derived SEMA7A as a key driver of atherosclerosis through a novel integrin β1/JNK/MSR1 axis, providing potential targets for the prevention and treatment of atherosclerosis.

Indexed as

atherosclerosislipid uptakemacrophageSEMA7A

Identifiers

PMID41402696

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.