Evidence map›Paper›PMID 41402686›Full record

ReviewPharmaceutical research2026

Multi-Target Anticoagulant Regulation by Peptides from Medicinal Leeches: A Unique Natural Strategy against Thrombosis.

Feng Shi, Qingmei Hu, Yiquan Lin, Sijia Fan, Xueting Cao, Dezhi Yang, Yuanhai Chen, Dejun Kong, Kaiqing Liu, Zichao Liu

Abstract readReview
PubMed Publisher
In one paragraph

Review in Pharmaceutical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Feng Shi *Engineering Research Center for Exploitation and Utilization of Leech Resources in Universities of Yunnan Province, School of Agriculture and Life Sciences, Kunming University, Kunming, 650214, China.
Qingmei Hu *Engineering Research Center for Exploitation and Utilization of Leech Resources in Universities of Yunnan Province, School of Agriculture and Life Sciences, Kunming University, Kunming, 650214, China.
Yiquan LinEngineering Research Center for Exploitation and Utilization of Leech Resources in Universities of Yunnan Province, School of Agriculture and Life Sciences, Kunming University, Kunming, 650214, China.
Sijia FanEngineering Research Center for Exploitation and Utilization of Leech Resources in Universities of Yunnan Province, School of Agriculture and Life Sciences, Kunming University, Kunming, 650214, China.
Xueting CaoEngineering Research Center for Exploitation and Utilization of Leech Resources in Universities of Yunnan Province, School of Agriculture and Life Sciences, Kunming University, Kunming, 650214, China.
Dezhi YangEngineering Research Center for Exploitation and Utilization of Leech Resources in Universities of Yunnan Province, School of Agriculture and Life Sciences, Kunming University, Kunming, 650214, China.
Yuanhai ChenEngineering Research Center for Exploitation and Utilization of Leech Resources in Universities of Yunnan Province, School of Agriculture and Life Sciences, Kunming University, Kunming, 650214, China.
Dejun KongSchool of Ecology and Environmental Science, Yunnan University, Kunming, 650500, China.
Kaiqing LiuEngineering Research Center for Exploitation and Utilization of Leech Resources in Universities of Yunnan Province, School of Agriculture and Life Sciences, Kunming University, Kunming, 650214, China.
Zichao LiuEngineering Research Center for Exploitation and Utilization of Leech Resources in Universities of Yunnan Province, School of Agriculture and Life Sciences, Kunming University, Kunming, 650214, China. abclzc@aliyun.com.ORCID http://orcid.org/0000-0002-7509-6209

Funding

Frontier Research Team of Kunming University 2023, the National Key R&D Program of China 2023YFF1305000Joint Special Project for Basic Research of Local Universities in Yunnan Province 202301BA070001-105National Natural Science Foundation of China 32260132Special Project of Science-Technology Talent and Platform in Yunnan Province 202105AC160042Yunnan International Joint Laboratory with South and Southeast Asia for the Integrated Development of Animal-Derived Anti-Thrombosis Chinese Medicine 202503AP140025Yunnan Provincial University Serving Key Industry Science and Technology Special Project FWCY-ZD2024009Yunnan Ten Thousand Talents Program for Young Top Notch Talents YNWR-QNBJ-2020-122
6 · The paper itself

Abstract

backgroundThrombotic diseases remain a major global health burden. Current anticoagulants are often limited by bleeding risks and narrow therapeutic windows, largely due to their single-target mechanisms. In contrast, medicinal leeches secrete diverse peptides that naturally and synergistically modulate multiple steps of the hemostatic system.

methodsThis paper systematically reviews published biochemical, structural, functional, and omics studies on leech-derived anticoagulant peptides, classifying them according to their molecular targets and antithrombotic mechanisms.

resultsLeech-derived peptides act synergistically at multiple key points of the coagulation cascade: (1) they inhibit platelet adhesion and aggregation by blocking the vWF-collagen interaction or suppressing GPIIb/IIIa; (2) they directly inhibit core coagulation proteases, such as thrombin and factor Xa; and (3) they interfere with fibrin stabilization and promote its dissolution by inhibiting factor XIIIa or modulating the fibrinolytic and intrinsic protease systems. From a molecular perspective, multispecies omics analyses have revealed a significant expansion of antithrombotic gene families and identified numerous novel peptide candidate genes.

conclusionsLeech-derived peptides provide a unique natural platform for multi-target anticoagulation and represent promising leads for next-generation antithrombotic agents. Combining traditional purification with genomics-guided discovery will accelerate mechanism elucidation, structural optimization, and translational development.

Indexed as

AnticoagulantsLeechesPeptidesThrombosisAnimalsBlood CoagulationFibrinolytic AgentsHumansAnticoagulantsFibrinolytic AgentsPeptidesAnticoagulant peptidesBlood coagulationFibrinolytic activityMedicinal leechMulti-target mechanisms

Identifiers

PMID41402686

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.