Evidence map›Paper›PMID 41402684›Full record

ArticlePharmaceutical research2026

Intracerebral Distribution of Drugs with Diverse Blood-brain Barrier Transport Characteristics: In vivo Analysis using Brain Microdialysis in Cynomolgus Monkeys.

Takuya Fujita, Yukari Kamikozawa, Makoto Ozawa, Yoriko Tajima, Toshiki Kurosawa, Yuki Katagiri, Hiroko Kawaguchi, Akito Kakuuchi, Rei Miyamoto, Kentaro Wakayama and 7 more

Abstract read
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In one paragraph

Article in Pharmaceutical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Takuya Fujita *Laboratory of Molecular Pharmacokinetics, College of Pharmaceutical, Sciences, Ritsumeikan University, 1-1-1 Noji-Higashi, Kusatsu, Shiga, Japan. fujita-t@ph.ritsumei.ac.jp.ORCID http://orcid.org/0000-0002-7724-6522
Yukari Kamikozawa *DMPK Research Laboratories, Sohyaku Innovative Research Division, Tanabe Pharma Corporation, 1000 Kamoshida-Cho, Aoba-Ku, Yokohama, Japan.
Makoto Ozawa *Pharmaceutical and Analytical Research Department, Daiichi Sankyo RD Novare Co., Ltd., 1-16-13 Kitakasai, Edogawa, Tokyo, Japan.
Yoriko Tajima *Group 1, Pharmacokinetic Research Laboratories, Ono Pharmaceutical Co., Ltd., Ibaraki, Japan.
Toshiki KurosawaLaboratory of Drug Disposition and Pharmacokinetics, Faculty of Pharmaceutical Sciences, Teikyo University, 2-11-1 Kaga, Itabashi, Tokyo, Japan.
Yuki KatagiriPreclinical Research Unit, Research and Development Division, Sumitomo Pharma Co., Ltd., 3-1-98 Kasugade-Naka, Konohana-Ku, Osaka, Japan.
Hiroko KawaguchiPreclinical Research Unit, Research and Development Division, Sumitomo Pharma Co., Ltd., 3-1-98 Kasugade-Naka, Konohana-Ku, Osaka, Japan.
Akito KakuuchiSection 3, Oncology Medical Affairs, Ono Pharmaceutical Co., Ltd., Osaka, Japan.
Rei MiyamotoPharmacokinetics Research Laboratories, Taiho Pharmaceutical Co., , Ltd. 3 Okubo, Tsukuba, Ibaraki, Japan.
Kentaro WakayamaPharmacokinetics Research Laboratories, Taiho Pharmaceutical Co., , Ltd. 3 Okubo, Tsukuba, Ibaraki, Japan.
Mika NagaiDrug Research Center, KAKEN PHARMACEUTICAL CO., LTD, 14 Shinomiya Minamigawara-Cho, Yamashina-Ku, Kyoto, Japan.
Takayuki TaguchiDrug Research Center, KAKEN PHARMACEUTICAL CO., LTD, 14 Shinomiya Minamigawara-Cho, Yamashina-Ku, Kyoto, Japan.
Koji BesshoLaboratory for Safety Assessment and ADME, Pharmaceuticals Research Center, Asahi Kasei Pharma Corporation, 632-1, Mifuku, Izunokuni, Shizuoka, Japan.
Daisuke WatanabePharmaCo-Cell Company Ltd. , Dai-Ichi-Senshu Bldg. 2 Floor, 6-19, Chitose-Machi, Nagasaki, Japan.
Takuo OgiharaDevelopment for Drug Discovery Resources, Department of Medical and Life Sciences, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Yamazaki, Noda, Chiba, 2641, Japan.
Hiroyuki KusuharaLaboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, the University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku Tokyo, Japan.
Yoshiharu DeguchiLaboratory of Drug Disposition and Pharmacokinetics, Faculty of Pharmaceutical Sciences, Teikyo University, 2-11-1 Kaga, Itabashi, Tokyo, Japan. deguchi@pharm.teikyo-u.ac.jp.ORCID http://orcid.org/0000-0001-9904-9055

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe purpose of this study is to analyze the impact of the blood-brain barrier (BBB) and blood-cerebrospinal fluid barrier (BCSFB) transport characteristics of drugs on their intracerebral distribution in male cynomolgus monkeys.

methodsSteady-state concentrations of 15 drugs (13 drugs and 2 compounds) transported by passive diffusion or via solute carrier (SLC) and/or ATP-binding cassette (ABC) transporters were measured in the frontal cortex interstitial fluid (ISF), lateral ventricular cerebrospinal fluid (CSF) and lumbar CSF of monkey brain by means of microdialysis and lumbar puncture methods. The values of brain ISF (or CSF)/plasma unbound concentration ratio (K

resultsThe K

conclusionThe results of this study suggest that the intracerebral distribution of the test drugs from the blood in the monkey brain should consider the contribution of influx transporters as well as efflux transporters. In addition, the lumbar CSF concentrations of the test drugs appear to be a useful surrogate marker of the ISF concentrations.

Indexed as

Blood-Brain BarrierBrainAnimalsATP-Binding Cassette TransportersATP Binding Cassette Transporter, Subfamily B, Member 1Biological TransportMacaca fascicularisMaleMicrodialysisPharmaceutical PreparationsTissue DistributionATP-Binding Cassette TransportersATP Binding Cassette Transporter, Subfamily B, Member 1Pharmaceutical PreparationsBCRP/ABCB2blood–brain barrierblood-cerebrospinal barrierbrain microdialysiscynomolgus monkeyP-gp/MDR1SLC transporterstransporter

Identifiers

PMID41402684

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.