SynthesisInternational urology and nephrology2026
Understanding frailty across the kidney transplant continuum: a comprehensive systematic review of recent evidence.
Synthesis in International urology and nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimFrailty is a condition resulting from age-related decline in physical, cognitive, physiological, and immune reserves. It is increasingly recognized as an important clinical syndrome in patients with chronic kidney disease, with special relevance among those on the kidney transplant waitlist or who have undergone kidney transplantation. Therefore, a comprehensive understanding of its prevalence, risk factors, and impact on transplant outcomes in both kidney transplant candidates and kidney transplant recipients is essential. The aim of this systematic review is to provide a comprehensive understanding of frailty across the kidney transplant continuum, including its prevalence, predictive factors, clinical outcomes, assessment tools, and implications for clinical practice and future research, through an up-to-date synthesis of recent evidence.
methodsA comprehensive literature search was performed in PubMed, Web of Science, Ovid MEDLINE, Cochrane Library, and Scopus to identify relevant studies published up to May 1, 2025. The eligibility of studies was screened by 2 independent reviewers. Due to substantial heterogeneity in populations, frailty definitions, and outcomes, a narrative synthesis was performed instead of a meta-analysis. This systematic review was conducted in accordance with PRISMA guidelines and was registered in the PROSPERO database. RESULTS AND DISCUSSION: A total of 127 studies were included in this review. The reported prevalence of frailty among kidney transplant candidates ranged from 8.7 to 75%, while among transplant recipients it ranged from 5.1 to 40.5%. Several risk factors were consistently associated with frailty, including advanced age, diabetes, cardiovascular disease, and low physical performance. Frailty was linked to increased waitlist mortality, delayed graft function, prolonged hospital stay, higher risk of postoperative complications, and reduced graft and patient survival. Some studies reported partial or complete improvement in frailty status following kidney transplantation. Although the Physical Frailty Phenotype is the most used tool to assess frailty in studies, there is still no consensus on a standardized assessment method.
conclusionsFrailty is a critical condition that requires comprehensive assessment during the kidney transplantation process. Recent clinical research has focused on elucidating the mechanisms underlying the association between frailty and transplantation, and the insights gained may contribute to the development of more effective management strategies throughout the transplantation process.
Indexed as
Identifiers
41402678What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.