Evidence map›Paper›PMID 41402665›Full record

ArticleNature cardiovascular research2025

Human genetics implicate thromboembolism in the pathogenesis of long COVID in individuals of European ancestry.

Art Schuermans, Andreas Verstraete, Vilma Lammi, Tomoko Nakanishi, Maddalena Ardissino, Jef Van den Eynde, Benjamin B Sun, Marios K Georgakis, Beatriz Guillen-Guio, Louise V Wain and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature cardiovascular research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors.

Art SchuermansKU Leuven Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, Leuven, Belgium. aschuerm@broadinstitute.org.ORCID http://orcid.org/0000-0001-8146-9692
Andreas VerstraeteKU Leuven Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, Leuven, Belgium.ORCID http://orcid.org/0000-0003-2121-4713
Vilma LammiProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-3256-5239
Tomoko NakanishiDepartment of Human Genetics, McGill University, Montréal, Quebec, Canada.ORCID http://orcid.org/0000-0001-9510-5646
Maddalena ArdissinoBHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Jef Van den EyndeKU Leuven Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, Leuven, Belgium.ORCID http://orcid.org/0000-0002-5606-376X
Benjamin B SunDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-6347-2281
Marios K GeorgakisProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-3507-3659
Beatriz Guillen-GuioDepartment of Population Health Sciences, University of Leicester, Leicester, UK.
Louise V WainDepartment of Population Health Sciences, University of Leicester, Leicester, UK.
Christopher E BrightlingNIHR Leicester Biomedical Research Centre, Leicester, UK.
PHOSP-COVID Collaborative Group
Johan Van WeyenberghLaboratory of Clinical and Epidemiological Virology, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0003-3234-8426
Adam J LewandowskiNuffield Department of Population Health, University of Oxford, Oxford, UK.
Betty RamanDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Hugo ZebergDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-7118-1249
Hanna M OllilaProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-5302-6429
Stephen BurgessMRC Biostatistics Unit, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-5365-8760
Pradeep NatarajanProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-8402-7435
Michael C HonigbergProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-8630-5021
Kathleen FresonKU Leuven Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, Leuven, Belgium.ORCID http://orcid.org/0000-0002-4381-2442
Thomas VanasscheKU Leuven Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, Leuven, Belgium.
Peter VerhammeKU Leuven Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, Leuven, Belgium.ORCID http://orcid.org/0000-0001-8698-2858

Funding

Long COVID as a putative subtype of chronic fatigue syndromeR01AI170850 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Richa Saxena · 2022 to 2026
$2.2M
Academy of Finland (Suomen Akatemia) #1350181Deutsche Forschungsgemeinschaft (German Research Foundation) 512461526Fonds Wetenschappelijk Onderzoek (Research Foundation Flanders) 1843423NFonds Wetenschappelijk Onderzoek (Research Foundation Flanders) G072921NJapan Society for the Promotion of Science London (JSPS London) 22J30004Knut och Alice Wallenbergs Stiftelse (Knut and Alice Wallenberg Foundation) 2023.0141KU Leuven (Katholieke Universiteit Leuven) C14/23/121NIAID NIH HHS R01 AI170850U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01AI170850U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01Hl161365Vetenskapsrådet (Swedish Research Council) 2021-03050Wellcome Trust 221680Wellcome Trust 302210Wellcome Trust (Wellcome) 221680/Z/20/ZWellcome Trust (Wellcome) 302210/Z/23/Z
6 · The paper itself

Abstract

SARS-CoV-2 infection can result in long COVID, characterized by post-acute symptoms from multiple organs. Current hypotheses on mechanisms underlying long COVID include persistent inflammation and thromboembolism; however, compelling evidence from humans is limited and causal associations remain unclear. In this study, we tested the association of thromboembolism-related genetic variants with long COVID in the Long COVID Host Genetics Initiative (n

Indexed as

COVID-19Venous ThromboembolismWhite PeopleFemaleGenetic Predisposition to DiseaseHumansMaleMiddle AgedPolymorphism, Single NucleotideRisk Factors

Identifiers

PMID41402665
PMCPMC7618558

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.