Evidence map›Paper›PMID 41402639›Full record

ArticlePediatric research2026

Cardiorespiratory signatures of necrotizing enterocolitis: a 4-NICU study of very low birth weight infants.

Sherry L Kausch, Zachary A Vesoulis, Colm P Travers, Carie Taveras, Rachel Benz, Amanda Duncan, Angela K S Gummadi, Katy N Krahn, Rakesh Sahni, Joseph Isler and 5 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Sherry L KauschDepartment of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA, USA. slk7s@uvahealth.org.
Zachary A VesoulisDepartment of Pediatrics, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
Colm P TraversDepartment of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA.
Carie TaverasDepartment of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Rachel BenzDepartment of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA.
Amanda DuncanDepartment of Pediatrics, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
Angela K S GummadiDepartment of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA, USA.
Katy N KrahnDepartment of Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA.
Rakesh SahniDepartment of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Joseph IslerDepartment of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Namasivayam AmbalavananDepartment of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA.
J Randall MoormanDepartment of Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA.
Douglas E LakeDepartment of Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA.
Karen D FairchildDepartment of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA, USA.
Brynne A SullivanDepartment of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA, USA.

Funding

Predictive Informatics Monitoring in the Neonatal Intensive Care UnitR01HD072071 · NICHD · UNIVERSITY OF VIRGINIA · PI KAREN D FAIRCHILD, Brynne Archer Sullivan · 2014 to 2026
$7.6M
Cross-species analysis of myocardial susceptibility to perioperative stressR01HL092071 · NHLBI · DUKE UNIVERSITY · PI PODGOREANU, MIHAI V. · 2007 to 2010
$1.9M
Integrated physiomarker, biomarker and clinical predictive analytics for early warning of sepsis and necrotizing enterocolitis in very low birth weight infants.K23HD097254 · NICHD · UNIVERSITY OF VIRGINIA · PI SULLIVAN, BRYNNE ARCHER · 2019 to 2023
$897k
Non-invasive oscillometry to measure lung mechanics, response to treatments, and predict longer-term pulmonary outcomes among preterm infants: a prospective cohort studyK23HL157618 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Colm Peter Travers · 2022 to 2026
$862k
Racial Disparities in Preterm Brain Injury Are Driven by Differences in Cerebral AutoregulationK23NS111086 · NINDS · WASHINGTON UNIVERSITY · PI VESOULIS, ZACHARY ANDREW · 2019 to 2022
$736k
NHLBI NIH HHS K23 HL157618NHLBI NIH HHS R01 HL092071NICHD NIH HHS K23 HD097254NICHD NIH HHS R01 HD072071NINDS NIH HHS K23 NS111086
6 · The paper itself

Abstract

backgroundNecrotizing enterocolitis (NEC) is a disorder in very low birth weight (VLBW, <1500 g) infants, associated with significant morbidity and mortality. Earlier detection of NEC may improve outcomes. We hypothesized that NEC's physiological signature resembles that of sepsis and that our model developed for sepsis, the Pulse Oximetry Warning System (POWS), would also predict NEC.

objectivesAssess relationships between continuous heart rate (HR) and oxygen saturation (SpO

methodsIn a retrospective multicenter analysis, we studied VLBW infants at four level IV NICUs, identifying cases of late-onset sepsis (LOS) and NEC (Bell stages 2 or 3). Using HR and SpO

resultsAmong 3914 infants evaluated, 5% had NEC and 13% had LOS. Cardiorespiratory data analysis showed that HR/SpO

conclusionNEC shares a cardiorespiratory signature with LOS. POWS predicted NEC with a dynamic rise before clinical diagnosis. IMPACT: A cardiorespiratory early warning score analyzing heart rate and oxygen saturation, trained to predict late-onset sepsis within 24h across, predicts necrotizing enterocolitis. Heart rate and oxygen saturation features had the same patterns of association with necrotizing enterocolitis as sepsis. The results increase understanding of physiologic signatures of neonatal sepsis and necrotizing enterocolitis.

Indexed as

Enterocolitis, NecrotizingHeart RateInfant, Very Low Birth WeightIntensive Care Units, NeonatalFemaleHumansInfant, NewbornMaleOximetryOxygenOxygen SaturationRetrospective StudiesRisk FactorsSepsisOxygen

Identifiers

PMID41402639
PMCPMC13042325

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.