Evidence map›Paper›PMID 41402549›Full record

ArticleInflammation2025

TREML2 Modulates Microglial Phagocytosis of Myelin Debris via TLR9 in Chronic Cerebral Ischemia.

Zhao-Han Xu, Jing-Wen Qi, Xin-Yu He, Shi-Yao Wang, Shuai-Yu Chen, Yu-Cheng Gu, Yi Xie, Ying-Dong Zhang, Teng Jiang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Inflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhao-Han Xu *Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China.
Jing-Wen Qi *Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China.
Xin-Yu He *Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China.
Shi-Yao WangDepartment of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China.
Shuai-Yu ChenDepartment of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China.
Yu-Cheng GuDepartment of Nuclear Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China.
Yi XieDepartment of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China. xieyi@njmu.edu.cn.ORCID http://orcid.org/0000-0001-8095-4856
Ying-Dong ZhangDepartment of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China. zhangyingdong@njmu.edu.cn.ORCID http://orcid.org/0000-0001-7803-5367
Teng JiangDepartment of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China. jiang_teng@njmu.edu.cn.ORCID http://orcid.org/0000-0003-4170-1156

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Demyelination is a significant pathological feature of chronic cerebral ischemia. Recent evidence suggested that microglia played a protective role in mitigating brain ischemic injury via phagocytosis of myelin debris resulting from demyelination. Triggering receptor expressed on myeloid cells-like 2 (TREML2) is a newly discovered inflammation-associated transmembrane receptor expressed by microglia. To date, whether microglial TREML2 contributes to the phagocytosis of myelin debris in chronic cerebral ischemia has not been fully clarified. In this study, employing a bilateral carotid artery stenosis animal model and a CoCl

Indexed as

Brain IschemiaMembrane GlycoproteinsMicrogliaMyelin SheathPhagocytosisReceptors, ImmunologicToll-Like Receptor 9AnimalsChronic DiseaseDemyelinating DiseasesMaleMiceMice, Inbred C57BLMice, KnockoutMembrane GlycoproteinsReceptors, ImmunologicToll-Like Receptor 9Chronic cerebral ischemiaDemyelinationMicrogliaPhagocytosisTLR9TREML2

Identifiers

PMID41402549
PMCPMC12712029

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.