Evidence map›Paper›PMID 41402534›Full record

ArticleScientific reports2025

Ketamine and metabolites in snake venom: effects of venom extraction and potential impact on animal models.

Kerstin Damm, Christoph Hartwig, Andreas Vilcinskas, Stephen P Mackessy, Tim Lüddecke, Maik Damm

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kerstin Damm *Justus-Liebig-University Giessen, Giessen, Germany.
Christoph HartwigBranch for Bioresources, Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Ohlebergsweg 12, 35392, Giessen, Germany.
Andreas VilcinskasBranch for Bioresources, Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Ohlebergsweg 12, 35392, Giessen, Germany.
Stephen P MackessyDepartment of Biological Sciences, University of Northern Colorado, Greeley, CO, 80639, USA.
Tim LüddeckeBranch for Bioresources, Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Ohlebergsweg 12, 35392, Giessen, Germany.
Maik Damm *Institute of Insect Biotechnology, Justus-Liebig-University Giessen, Heinrich-Buff-Ring 26-32, 35392, Giessen, Germany. maik.damm@agrar.uni-giessen.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In zootoxinology, drugs such as anesthetics and secretion enhancers are used to increase venom yields, but it is unclear whether this affects the venom composition. After injection of ketamine and pilocarpine into two non-front-fanged snakes, mass spectrometry confirmed the presence of both drugs and their metabolites in the venoms. The quantified high concentrations raise concerns about potential interference in bioassays and pharmacological studies, highlighting the need to consider extraction additives in venom research to ensure unbiased results.

Indexed as

KetamineSnakesSnake VenomsAnimalsMaleMass SpectrometryModels, AnimalPilocarpineTissue DistributionToxicologyKetaminePilocarpineSnake VenomsDrugsMass spectrometryMetabolismQuantification

Identifiers

PMID41402534
PMCPMC12712038

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.