SynthesisJournal of cancer research and clinical oncology2025
Hematological parameters as predictors of oral cancer prognosis: a systematic review and meta-analysis.
Synthesis in Journal of cancer research and clinical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Preoperative Inflammatory Blood Indices as Prognostic Markers in Oral Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2026Pooled it
- The Relationship Between Severity of Apical Periodontitis and Next-Generation Systemic Inflammatory Biomarkers.Australian endodontic journal : the journal of the Australian Society of Endodontology Inc · 2026Article
- Clinical Significance of Neutrophil-to-Lymphocyte Ratio and Lymphocyte-to-Monocyte Ratio in Oral Squamous Cell Carcinoma.Diagnostics (Basel, Switzerland) · 2026Article
- Clinical and laboratory biomarker correlates of lip, oral cavity, and pharyngeal cancer status in a large retrospective clinical database.Frontiers in oral health · 2026Article
- Pretreatment Geriatric Nutritional Risk Index in RADPLAT-treated Patients With Oral Squamous Cell Carcinoma: A Pilot Study.In vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectiveThis systematic review and meta-analysis aimed to assess the prognostic value of pre-treatment hematological parameters, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV), in patients with oral squamous cell carcinoma (OSCC).
methodsA systematic search of PubMed, Embase, Scopus, Web of Science, ScienceDirect, and Google Scholar was conducted until April 2025. We included English-language observational studies reporting associations between NLR, PLR, MPV, and survival or clinicopathological outcomes in OSCC. Data extraction and risk of bias assessment using the Newcastle-Ottawa Scale were performed independently by two reviewers. Hazard ratios (HRs) and odds ratios (ORs) were pooled using a random-effects model. The certainty of evidence was evaluated using the GRADE.
resultsThirty-five studies (approximately 7940 patients) were included. A high NLR was associated with worse overall survival (pooled HR 1.59, 95% CI 1.32-1.92) and disease-free survival (HR 1.66, 95% CI 1.31-2.10). PLR showed similar associations with overall survival (HR 1.58, 95% CI 1.29-1.94) and disease-free survival (HR 1.50, 95% CI 1.18-1.90). Between-study heterogeneity was moderate to high in this study. MPV findings were inconsistent and not pooled.
conclusionsElevated NLR and PLR correlate with poorer outcomes in OSCC, with effect sizes varying by study design and cut-off selection. These blood-based indices may aid in risk stratification; however, prospective validation with standardized thresholds is required.
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