ArticleNature cell biology2025
Modelling co-development between the somites and neural tube in human trunk-like structures.
Article in Nature cell biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Lineage tracing in gastruloids to understand determinants of early fate decisions.Current opinion in genetics & development · 2026Review
- Decoding the origins of cellular self-organization for engineered biology.Nature biotechnology · 2026Review
- Stem cell-based embryo models as a tool for reproductive biology.Molecular human reproduction · 2026Review
- Morally relevant features warranting ethical oversight in human stem cell-based embryo models.Nature cell biology · 2026Review
- A guide to using embedded ethics in human stem-cell-based embryo model research.Nature cell biology · 2026Review
- Optogenetic WNT signaling drives germ layer self-organization in a human gastruloid model.bioRxiv : the preprint server for biology · 2026Article
- Organizers in a dish: Modeling human CNS morphogenesis.Developmental cell · 2026Review
- Dual-patterned pluripotent stem cells self-organize into a human embryo model with extended anterior-posterior patterning.bioRxiv : the preprint server for biology · 2025Article
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7 authors.
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Abstract
Human stem cell-based embryo models provide experimentally amenable in vitro systems for developmental research. A key feature of embryo models is their multi-lineage differentiation, which allows for the study of tissue co-development. Here we develop human trunk-like structures that have morphologically organized somites and a neural tube that form through self-organized, endogenous signalling. Transcriptomic comparison with human embryo datasets suggests that human trunk-like structure cells approximate Carnegie stage 13-14 (28-35 days after fertilization). The absence of a notochord leads to a dorsal identity, but exogenous Sonic Hedgehog signalling activation ventralizes both the somites and the neural tube in a dose-dependent manner. We further identify reciprocal signalling: neural tube-derived cues induce medial ALDH1A2 in somites, which in turn generate retinoic acid signals that drive spontaneous neural-tube patterning. Together, our data highlight the value of modularity in embryo models, which we leverage to explore human trunk co-development.
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