Transaminase-catalyzed sequential hydrodefluorinations of perfluorinated methylene groups.

Xiaoyang Chen, Yuting Zhang, Juying Fu, Ziyi Chen, Xinyi Zhou, Xiaohe Chu

Abstract read

In one paragraph

Article in Communications chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Decoding cryptic defluorinases through a latent generative sequence landscape.Chemical science · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiaoyang ChenCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, China. chenxychem@zjut.edu.cn.ORCID http://orcid.org/0000-0001-8006-3279

Yuting ZhangCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, China.

Juying FuCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, China.

Ziyi ChenCollege of Energy Environment and Safety Engineering, China Jiliang University, Hangzhou, Zhejiang, China.

Xinyi ZhouCollege of Energy Environment and Safety Engineering, China Jiliang University, Hangzhou, Zhejiang, China. xinyizhou@cjlu.edu.cn.ORCID http://orcid.org/0009-0009-5825-6635

Xiaohe ChuCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, China. chuxhe@zjut.edu.cn.ORCID http://orcid.org/0000-0001-6398-5917

Funding

National Natural Science Foundation of China (National Science Foundation of China) 22201106National Natural Science Foundation of China (National Science Foundation of China) 22477112

6 · The paper itself

Abstract

Biocatalysis represents a particularly promising approach for the degradation of recalcitrant fluorochemicals. However, the enzymatic activation of perfluorinated methylene groups remains a challenge, primarily due to the increase in C-F bond strength that correlates with the number of fluorine atoms attached to a single carbon atom. Here, we describe a new-to-nature hydrodefluorination reaction catalyzed by engineered transaminases for the biodegradation of difluorinated fused-ring ketones. Remarkable defluorination efficiency was achieved in most cases by employing a slight excess of 2-PrNH

Identifiers

PMID41402455

DOI10.1038/s42004-025-01781-y

PMCPMC12708621

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.