Evidence map›Paper›PMID 41402427›Full record

ArticleScientific reports2025

Association of higher triglyceride glucose index and triglyceride to high density lipoprotein cholesterol ratio with early-onset post-stroke depression.

Mingzhu Deng, Zhen Wang, Wei Zhao, Wei Xu, Sufen Chen, Xiugui Ma, Kangping Song, Fangyi Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mingzhu Deng *Department of Neurology, The Second People's Hospital of Hunan Province (Brain Hospital of Hunan Province), Changsha, Hunan, China.
Zhen Wang *Department of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China.
Wei ZhaoDepartment of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China.
Wei XuDepartment of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China.
Sufen ChenDepartment of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China.
Xiugui MaDepartment of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China.
Kangping SongDepartment of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China. 18936279753@163.com.
Fangyi LiDepartment of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China. 475040942@qq.com.

Funding

Hunan Science and Technology Innovation Key Project 2020SK1012Medical Clinical Research 4310 Project of University of South China KJZX2021078Natural Science Foundation of Hunan Province 2023JJ40072Science and Technology Planning Project of Hunan Health Committee D202303076376
6 · The paper itself

Abstract

The prognosis of stroke is related to insulin resistance (IR), and post-stroke depression (PSD) is a prevalent psychological consequence following a stroke. The triglyceride-to-glucose (TyG) index and the triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio are simple and accurate markers of insulin resistance. However, the relationship between early-onset PSD and TyG index or TG/HDL-C ratio remains unknown. The Hamilton Depression Scale-17 item (HAMD-17) was used to assess the severity of depression. After two weeks of acute ischemic stroke (AIS), patients with HAMD-17 ≥ 7 were defined as early-onset post-stroke depression. Among the 543 recruited patients, a total of 206 (38%) patients were diagnosed with early-onset PSD. The logistic regression model determined that early-onset PSD was independently associated with the TyG index (odds ratio [OR], 1.915; 95% confidence interval [CI] 1.665-2.115, P < 0.001) and TG/HDL-C ratio (OR, 1.458; 95% CI 1.213-1.965, P = 0.002). The area under curve (AUC) of TyG index, TG/HDL-C ratio, and TyG index combined TG/HDL-C ratio to predict early-onset PSD was 0.765, 0.705, and 0.813, respectively. According to our research, the TG/HDL-C ratio and the TyG index could serve as independent risk factors and prediction indicators for early-onset PSD.

Indexed as

Blood GlucoseCholesterol, HDLDepressionStrokeTriglyceridesAgedBiomarkersFemaleHumansInsulin ResistanceMaleMiddle AgedRisk FactorsBiomarkersBlood GlucoseCholesterol, HDLTriglyceridesAcute ischemic strokeInsulin resistancePost-stroke depressionTriglyceride–glucose indexTriglyceride-to-high-density lipoprotein cholesterol ratio

Identifiers

PMID41402427
PMCPMC12708625

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.