Evidence map›Paper›PMID 41402325›Full record

ArticleNature communications2025

Multi-layered transcriptional control of glycogen metabolism coordinates thermogenic remodeling of white adipocytes in male mice.

Haipeng Fu, Seoyeon Lee, Nathan R Zemke, Weiwei Fan, Yunqing Wang, James Garza, David Tin, Bryce Villao, Bichen Zhang, Xianda Ma and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Haipeng FuDivision of Endocrinology and Metabolism, Departments of Medicine and Pharmacology, University of California San Diego, San Diego, CA, USA.ORCID http://orcid.org/0000-0001-5749-2913
Seoyeon LeeDepartment of Cellular and Molecular Medicine, University of California, San Diego School of Medicine, San Diego, CA, USA.
Nathan R ZemkeDepartment of Cellular and Molecular Medicine, University of California, San Diego School of Medicine, San Diego, CA, USA.
Weiwei FanGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Yunqing WangDivision of Endocrinology and Metabolism, Departments of Medicine and Pharmacology, University of California San Diego, San Diego, CA, USA.
James GarzaDivision of Endocrinology and Metabolism, Departments of Medicine and Pharmacology, University of California San Diego, San Diego, CA, USA.
David TinDivision of Endocrinology and Metabolism, Departments of Medicine and Pharmacology, University of California San Diego, San Diego, CA, USA.
Bryce VillaoDivision of Endocrinology and Metabolism, Departments of Medicine and Pharmacology, University of California San Diego, San Diego, CA, USA.
Bichen ZhangDivision of Endocrinology and Metabolism, Departments of Medicine and Pharmacology, University of California San Diego, San Diego, CA, USA.
Xianda MaDivision of Endocrinology and Metabolism, Departments of Medicine and Pharmacology, University of California San Diego, San Diego, CA, USA.
Jinyang ZhangDivision of Endocrinology and Metabolism, Departments of Medicine and Pharmacology, University of California San Diego, San Diego, CA, USA.
Tangran DongDivision of Endocrinology and Metabolism, Departments of Medicine and Pharmacology, University of California San Diego, San Diego, CA, USA.
Yuyao RenDivision of Endocrinology and Metabolism, Departments of Medicine and Pharmacology, University of California San Diego, San Diego, CA, USA.
Michael DownesGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Ronald M EvansGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-9986-5965
Bing RenDepartment of Cellular and Molecular Medicine, University of California, San Diego School of Medicine, San Diego, CA, USA.
Alan R SaltielDivision of Endocrinology and Metabolism, Departments of Medicine and Pharmacology, University of California San Diego, San Diego, CA, USA. asaltiel@health.ucsd.edu.ORCID http://orcid.org/0000-0002-9726-9828

Funding

VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DIANE M SIMEONE · 1985 to 2026
$124.9M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4M
San Diego Digestive Diseases Research CenterP30DK120515 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LARS ECKMANN, Bernd G. Schnabl · 2019 to 2026
$10.8M
Regulation of Glycogen in Health and DiseaseR01DK117551 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ALAN R. SALTIEL · 2018 to 2026
$3.8M
Regulating energy expenditure in adipose tissueR01DK124496 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SALTIEL, ALAN R. · 2020 to 2024
$2.7M
Hormonal Regulation of Mammalian Gene ExpressionR01DK057978 · NIDDK · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI EVANS, RONALD M · 2021 to 2024
$2.6M
Adipose tissue plasticity in health and diseaseR01DK122804 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SALTIEL, ALAN R., WEISS, STEPHEN J · 2020 to 2023
$2.4M
Inflammation and hepatic lipid metabolismR01DK125820 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SALTIEL, ALAN R. · 2020 to 2023
$2.1M
Hormonal regulation of LDL receptor traffickingR01DK128796 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SALTIEL, ALAN R. · 2021 to 2024
$1.8M
Illumina NovaSeq 6000 Sequencing SystemS10OD026929 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEPSEN, KRISTEN LYNN · 2019 to 2019
$600k
American Diabetes Association (ADA) 315903-00001American Heart Association (American Heart Association, Inc.) 24POST1187840NCI NIH HHS P30 CA023100NIDDK NIH HHS P30 DK063491NIDDK NIH HHS P30 DK120515NIDDK NIH HHS R01 DK057978NIDDK NIH HHS R01 DK117551NIDDK NIH HHS R01 DK122804NIDDK NIH HHS R01 DK124496NIDDK NIH HHS R01 DK125820NIDDK NIH HHS R01 DK128796NIH HHS S10 OD026929U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) P30DK063491, P30DK120515, R01DK122804, R01DK124496, R01DK125820 and R01DK128796
6 · The paper itself

Abstract

Thermogenic activation of subcutaneous white adipocytes requires glycogen synthesis and turnover. Here we show that β-adrenergic stimulation induces a distinct glycogen metabolism gene program in inguinal white adipose tissue in a cell-autonomous and adipocyte-specific manner. Among these, Gys2 and Ppp1r3c are rapidly induced following acute β3-adrenergic receptor activation. We identify Gys2 as a direct transcriptional target of PKA-CREB signaling. In contrast, sustained expression of glycogen metabolism genes under chronic β3-adrenergic activation requires the coactivator PGC1α, whose loss blunts glycogen accumulation and thermogenic capacity. Mechanistically, PGC1α cooperates with estrogen-related receptors (ERRs) to regulate chromatin accessibility and gene transcription. Although deletion of ERRα is compensated by ERRγ, combined deletion of ERRα/β/γ abolishes expression of glycogen metabolism and thermogenic genes. Chromatin profiling confirm that ERRs directly control the glycogen metabolic program in beige adipocytes. Together, our results identify a multilayered transcriptional axis that sustains glycogen metabolism during β-adrenergic activation in male mice.

Indexed as

Adipocytes, WhiteGlycogenThermogenesisAdipocytes, BeigeAnimalsCyclic AMP-Dependent Protein KinasesCyclic AMP Response Element-Binding ProteinGene Expression RegulationMaleMiceMice, Inbred C57BLMice, KnockoutPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaReceptors, Adrenergic, beta-3Receptors, EstrogenSignal TransductionCyclic AMP-Dependent Protein KinasesCyclic AMP Response Element-Binding ProteinEsrrg protein, mouseGlycogenPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPpargc1a protein, mouseReceptors, Adrenergic, beta-3Receptors, Estrogen

Identifiers

PMID41402325
PMCPMC12824187

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.