Evidence map›Paper›PMID 41402305›Full record

ArticleNature communications2025

METTL3 safeguards cell identity and epigenome of human trophoblast stem cells.

Haifeng Fu, Chunxiao Chen, Yunying Huang, Weiyu Zhang, Shilong Li, For-Fan Chan, Ling Xu, Degong Ruan, Xiangyu Ouyang, Liyang Ma and 11 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Emerging roles of mJournal of assisted reproduction and genetics · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Haifeng Fu *School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China. hffu89@outlook.com.ORCID http://orcid.org/0000-0003-1174-9220
Chunxiao Chen *State Key Laboratory of Medicinal Chemical Biology, Frontiers Science Center for Cell Responses, College of Life Sciences, Nankai University, Tianjin, China.ORCID http://orcid.org/0009-0007-8463-9301
Yunying Huang *School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.ORCID http://orcid.org/0009-0007-9911-8939
Weiyu Zhang *InnoHK Centre for Translational Stem Cell Biology, Hong Kong Special Administrative Region, China.ORCID http://orcid.org/0000-0002-9530-8088
Shilong LiWeifang People's Hospital, Weifang, Shandong Province, China.
For-Fan ChanState Key Laboratory of Liver Research and Department of Pathology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Special Administrative Region, Hong Kong, China.
Ling XuSchool of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.
Degong RuanInnoHK Centre for Translational Stem Cell Biology, Hong Kong Special Administrative Region, China.
Xiangyu OuyangSchool of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.
Liyang MaSchool of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.
Zhen FengInnoHK Centre for Translational Stem Cell Biology, Hong Kong Special Administrative Region, China.
Qingqing ZhangSchool of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.
Chunyan WangWeifang People's Hospital, Weifang, Shandong Province, China.
Dai HengDepartment of Traditional Chinese Medicine, Peking University Third Hospital, Beijing, China.
Kexin YaoState Key Laboratory of Medicinal Chemical Biology, Frontiers Science Center for Cell Responses, College of Life Sciences, Nankai University, Tianjin, China.
Asif JavedSchool of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.ORCID http://orcid.org/0000-0002-6945-9624
Chun-Ming WongState Key Laboratory of Liver Research and Department of Pathology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Special Administrative Region, Hong Kong, China.ORCID http://orcid.org/0000-0002-2497-7858
Yin Lau LeeInnoHK Centre for Translational Stem Cell Biology, Hong Kong Special Administrative Region, China.ORCID http://orcid.org/0000-0003-0559-4381
William Shu Biu YeungInnoHK Centre for Translational Stem Cell Biology, Hong Kong Special Administrative Region, China.ORCID http://orcid.org/0000-0003-0670-0879
Baofa SunState Key Laboratory of Medicinal Chemical Biology, Frontiers Science Center for Cell Responses, College of Life Sciences, Nankai University, Tianjin, China. sunbf@nankai.edu.cn.ORCID http://orcid.org/0000-0002-8221-1279
Pentao LiuSchool of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China. pliu88@hku.hk.ORCID http://orcid.org/0000-0001-5774-9678

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

N6-methyladenosine (m

Indexed as

EpigenomeMethyltransferasesStem CellsTrophoblastsAdenosineCell DifferentiationEnhancer of Zeste Homolog 2 ProteinEpigenesis, GeneticFemaleHumansMethylationPlacentaPre-EclampsiaPregnancyAdenosineEnhancer of Zeste Homolog 2 ProteinMethyltransferasesMETTL3 protein, humanN-methyladenosine

Identifiers

PMID41402305
PMCPMC12823569

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.