Evidence map›Paper›PMID 41402173›Full record

ArticleDrug and alcohol dependence2026

Prescribing of controlled substances to adolescents and young adults enrolled in Medicaid, 2001-2019.

Greta Bushnell, Mark Olfson, Kristen Lloyd, Stephanie Shiau, Tobias Gerhard, Katherine M Keyes, Deborah Hasin, Magdalena Cerdá, Hillary Samples

Abstract read
In one paragraph

Article in Drug and alcohol dependence, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Greta BushnellCenter for Pharmacoepidemiology and Treatment Science, Rutgers Institute for Health, Health Care Policy and Aging Research, New Brunswick, NJ, United States; Department of Biostatistics and Epidemiology, Rutgers University School of Public Health, Piscataway, NJ, United States. Electronic address: greta.bushnell@rutgers.edu.
Mark OlfsonColumbia University Mailman School of Public Health, New York, NY, United States; Department of Psychiatry, Columbia University Irving Medical Center, New York, NY.
Kristen LloydCenter for Pharmacoepidemiology and Treatment Science, Rutgers Institute for Health, Health Care Policy and Aging Research, New Brunswick, NJ, United States.
Stephanie ShiauDepartment of Biostatistics and Epidemiology, Rutgers University School of Public Health, Piscataway, NJ, United States.
Tobias GerhardCenter for Pharmacoepidemiology and Treatment Science, Rutgers Institute for Health, Health Care Policy and Aging Research, New Brunswick, NJ, United States; Department of Pharmacy Practice and Administration, Ernest Mario School of Pharmacy, Rutgers University, New Brunswick, NJ, United States.
Katherine M KeyesColumbia University Mailman School of Public Health, New York, NY, United States.
Deborah HasinColumbia University Mailman School of Public Health, New York, NY, United States; Department of Psychiatry, Columbia University Irving Medical Center, New York, NY.
Magdalena CerdáCenter for Opioid Epidemiology and Policy, Department of Population Health, NYU Grossman School of Medicine, , New York, NY, United States.
Hillary SamplesCenter for Pharmacoepidemiology and Treatment Science, Rutgers Institute for Health, Health Care Policy and Aging Research, New Brunswick, NJ, United States; Department of Health Behavior, Society and Policy, Rutgers University School of Public Health, Piscataway, NJ, United States.

Funding

ADHD and Sleep: Evaluating the Impact of Drug-Drug and Drug-Disease Interactions to Inform CareR01MH135875 · NIMH · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI Greta Bushnell · 2025 to 2026
$1.3M
Benzodiazepine-related harms in young people: Informing policy, interventions, and prescribingK01DA050769 · NIDA · RUTGERS BIOMEDICAL/HEALTH SCIENCES-RBHS · PI BUSHNELL, GRETA · 2021 to 2025
$1.0M
NIDA NIH HHS K01 DA050769NIMH NIH HHS R01 MH135875
6 · The paper itself

Abstract

objectiveTo examine nationwide trends in the prescribing of controlled medications to early adolescents, adolescents, and young adults enrolled in public insurance (Medicaid) from 2001 to 2019.

methodsThe study utilized US Medicaid data covering publicly insured enrollees from 43 states (2001-2019). Early adolescents (10-12y), adolescents (13-17y), and young adults (18-24y, 25-29y) with ≥ 10 months enrollment in each calendar year were included. Filled prescription for opioids, stimulants, benzodiazepines, Z-hypnotics, barbiturates, and gabapentin were identified. In each calendar year, annual proportions with 1 +  controlled medication, 2 +  classes of controlled medications, and each controlled medication were estimated.

resultsIn 2019, the sample included 17.9 million enrollees (53 % female). The annual proportion prescribed any controlled medication peaked at 17.5 % in early adolescents (2003), 20.6 % in adolescents (2009), and 34.1 % (18-24y) and 47.0 % (25-29y) in young adults (2010). By 2019, the proportions declined to 11.7 % (early adolescents), 12.6 % (adolescents), 16.2 % (18-24y), and 23.9 % (25-29y). Trends varied by medication and age. The largest absolute decline was in the proportion with an opioid filled (2010 =29.8 %, 2019 =11.2 %, young adults 18-24y; 2003 =14.3 %, 2019 =4.4 %, adolescents). In contrast, the proportion with a stimulant fill increased, with eight-fold increases in young adults 25-29y (2001 =0.3 %, 2019 =2.6 %). Benzodiazepine and Z-hypnotic use peaked in 2010 and declined through 2019.

conclusionsIn the past two decades, there were increases in stimulant prescriptions among young Medicaid enrollees. The declines in opioid, benzodiazepines, barbiturate and Z-hypnotic prescribing are encouraging and may indicate more cautious prescribing related to greater awareness of harms such as misuse and overdose, along with policy initiatives.

Indexed as

Controlled SubstancesDrug PrescriptionsMedicaidPractice Patterns, Physicians'AdolescentAdultAnalgesics, OpioidBenzodiazepinesCentral Nervous System StimulantsChildFemaleGabapentinHumansHypnotics and SedativesMaleUnited StatesAnalgesics, OpioidBenzodiazepinesCentral Nervous System StimulantsControlled SubstancesGabapentinHypnotics and SedativesAdolescentBenzodiazepinesControlled substancesOpioidsPharmacotherapyStimulantsYoung adult

Identifiers

PMID41402173
PMCPMC13186604

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.