Evidence map›Paper›PMID 41402065›Full record

ReviewRNA (New York, N.Y.)2026

Decoding Argonaute specificity: insights from

Shihui Chen, Carolyn M Phillips

Abstract readReview
In one paragraph

Review in RNA (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Shihui ChenDepartment of Biological Sciences, University of Southern California, Los Angeles, California 90089-2910, USA.ORCID 0009-0006-3036-5475
Carolyn M PhillipsDepartment of Biological Sciences, University of Southern California, Los Angeles, California 90089-2910, USA cphil@usc.edu.ORCID 0000-0002-6228-6468

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Small noncoding RNAs are versatile regulators of gene expression, capable of guiding the silencing of complementary mRNAs through their association with Argonaute proteins. This RNA-guided silencing, known as RNA interference (RNAi), is a conserved mechanism that shapes diverse biological processes, from development to genome defense. Central to the effectiveness of RNAi is the precise loading of small RNAs into their appropriate Argonaute partners, a step that ensures both specificity and fidelity in target recognition. Although most organisms harbor multiple classes of small RNAs and a corresponding repertoire of Argonautes, the rules that dictate their selective pairing remain only partially understood.

Indexed as

Argonaute ProteinsCaenorhabditis elegansCaenorhabditis elegans ProteinsAnimalsRNA InterferenceRNA, Small InterferingRNA, Small UntranslatedArgonaute ProteinsCaenorhabditis elegans ProteinsRNA, Small InterferingRNA, Small UntranslatedArgonauteC. elegansgene regulationRNAismall RNA

Identifiers

PMID41402065
PMCPMC12908457

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.