ArticleThe Journal of international medical research2025
Downregulation of TMTC4 expression is associated with improved prognosis in osteosarcoma.
Article in The Journal of international medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
PurposeOsteosarcoma is the most common primary tumor of bone tissue. To date, the expression of transmembrane and tetratricopeptide repeat containing 4 (TMTC4) in osteosarcoma has not been reported. This study aimed to investigate the significance of TMTC4 in the prognosis of osteosarcoma.MethodsWe screened the expression of downstream genes after interleukin 11 receptor subunit alpha knockout in osteosarcoma using the Gene Expression Omnibus database. Data from The Cancer Genome Atlas database and a cloud-based platform were used to further analyze the expression levels and functional impact of TMTC4 in osteosarcoma, along with subgroup analysis. Polymerase chain reaction was used to detect TMTC4 expression in osteoblast and osteosarcoma cells, and a cell counting kit-8 assay was employed to assess cell proliferation.ResultsEleven downregulated genes, including
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