ArticleFunction (Oxford, England)2026
Anesthesia blocks the cardiovascular response to baroreceptor unloading in rats.
Article in Function (Oxford, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Baroreflex responsiveness and orthostatic stability in humans can be assessed by a variety of approaches, including exposure to graded levels of lower body negative pressure (LBNP). However, such approaches have limited applicability in animal studies owing to the need to anesthetize or sedate the animal. We recently reported a novel approach for the assessment of baroreceptor responsiveness in the awake rat using LBNP and presented preliminary findings that 3% isoflurane anesthesia completely blocked the normally robust baroreflex. In the present study, we sought to extend these findings by studying the effects of several common anesthetics on LBNP responsiveness. Blood pressure (BP) and heart rate (HR) responses to progressive levels of LBNP were first made in awake rats (male and female), followed by measurements under various anesthetics regimens:
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.