Evidence map›Paper›PMID 41401415›Full record

ArticleFunction (Oxford, England)2026

Intracellular calcium release activates carotid body afferents by fentanyl.

Ying-Jie Peng, Oren Kabil, Ning Wang, Zheng Xie, Aaron P Fox, Nanduri R Prabhakar

Abstract read
In one paragraph

Article in Function (Oxford, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Targeting the Carotid Body Function With Big-KPharmacology research & perspectives · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ying-Jie PengInstitute for Integrative Physiology and Center for Systems Biology of O2 sensing, The University of Chicago, Chicago, Illinois, United States.
Oren KabilInstitute for Integrative Physiology and Center for Systems Biology of O2 sensing, The University of Chicago, Chicago, Illinois, United States.
Ning WangInstitute for Integrative Physiology and Center for Systems Biology of O2 sensing, The University of Chicago, Chicago, Illinois, United States.
Zheng XieDepartment of Anesthesia and Critical Care, The University of Chicago, Chicago, Illinois, United States.
Aaron P FoxInstitute for Integrative Physiology and Center for Systems Biology of O2 sensing, The University of Chicago, Chicago, Illinois, United States.
Nanduri R PrabhakarInstitute for Integrative Physiology and Center for Systems Biology of O2 sensing, The University of Chicago, Chicago, Illinois, United States.ORCID 0000-0003-4570-1380

Funding

 opioid receptor activation of the carotid body mitigates OIRD by fentanylR01HL174373 · NHLBI · UNIVERSITY OF CHICAGO · PI Nanduri R Prabhakar · 2024 to 2026
$2.1M
NHLBI NIH HHS R01 HL174373
6 · The paper itself

Abstract

We recently reported [Peng YJ, Nanduri J, Wang N, Xie Z, Fox AP, Prabhakar NR.

Indexed as

Analgesics, OpioidCalciumCalcium SignalingCarotid BodyFentanylAnimalsHEK293 CellsHumansMaleRatsRats, Sprague-DawleyReceptors, Opioid, kappaAnalgesics, OpioidCalciumFentanylReceptors, Opioid, kappacarotid body afferentsG-protein coupled receptorsinositol trisphosphate (IP3)phospholipase C

Identifiers

PMID41401415
PMCPMC12790850

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.