ArticlePLOS global public health2025
Perceptions of persons deprived of liberty regarding tuberculosis vaccine research.
Article in PLOS global public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Interferon gamma release assay and sputum GeneXpert positivity for tuberculosis burden detection in people deprived of liberty in Brazil: a cross-sectional study.BMC public health · 2026Article
- Correction: Perceptions of persons deprived of liberty regarding tuberculosis vaccine research.PLOS global public health · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
22 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several tuberculosis (TB) vaccine candidates are currently advancing to late-stage clinical trials. Prisons in low-and middle-income countries harbor some of the highest rates of TB in the world, making persons deprived of liberty (PDL) an important population to prioritize for the introduction of effective vaccines. However, the inclusion in clinical trials raises significant ethical concerns due to a history of exploitation and mistreatment within medical research. To date, PDL own perspectives on participating in vaccine research have been largely overlooked. This multicenter qualitative study employed focus group (FG) discussions in seven state prisons across four of the five regions of Brazil, involving 91 incarcerated individuals (64 men and 27 female) between February and August 2024. The discussions explored participants' perceptions regarding health in prisons, TB, vaccines in general, new TB vaccines, and their potential participation in research. Participants reported encountering difficulties in accessing healthcare services within the prison system and shared personal or indirect experiences with TB, as well as concerns about their family members being at risk for TB exposure. While they generally held positive perceptions about vaccines and trials, they emphasized the need for clear and transparent information, respect for individual autonomy, and assurances of accountability from researchers as conditions of their willingness to participate in future trials. PDL perceptions regarding participation in clinical trials for new TB vaccines are significantly influenced by their prior experiences with the prison health system and their level of trust in research institutions. To ethically and effectively include PDL in future research, it is crucial to prioritize respect for autonomy and transparent communication about the risks and potential benefits involved.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.