Evidence map›Paper›PMID 41401159›Full record

ArticlePloS one2025

OphthoEvidence report: Baseline structural optical coherence tomography biomarkers predictive of visual acuity following epiretinal membrane surgery-A systematic review and meta-analysis protocol.

Xiajing Chu, João Pedro Lima, Dena Zeraatkar, Jinhui Ma, Femin Prasad, Sangeetha Srinivasan, Sobha Sivaprasad, Teresa Sandinha, Peter Kaiser, David H Steel and 3 more

Abstract read
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In one paragraph

Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xiajing ChuDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.ORCID https://orcid.org/0000-0002-6283-8074
João Pedro LimaDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.ORCID https://orcid.org/0000-0002-5486-7211
Dena ZeraatkarDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.
Jinhui MaDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.
Femin PrasadDivision of Ophthalmology, Department of Surgery, McMaster University, Hamilton, Ontario, Canada.ORCID https://orcid.org/0000-0002-5445-2489
Sangeetha SrinivasanDivision of Ophthalmology, Department of Surgery, St. Joseph's Health Care, Hamilton, Ontario, Canada.
Sobha SivaprasadNIHR Biomedical Research Centre at Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, United Kingdom.ORCID https://orcid.org/0000-0001-8952-0659
Teresa SandinhaSt Paul's Eye Unit, Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool, United Kingdom.
Peter KaiserCole Eye Institute, Cleveland Clinic, Cleveland, Ohio.
David H SteelBioscience Institute, Newcastle University, Newcastle Upon Tyne, United Kingdom.
Tien Yin WongSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Charles C WykoffRetina Consultants of Texas, Houston, Texas, Blanton Eye Institute, Houston Methodist Hospital, Houston, Texas, United States of America.
Varun ChaudharyDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.ORCID https://orcid.org/0000-0002-9988-4146

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEpiretinal membrane is a common retinal condition, particularly in the elderly, than can lead to reduced visual acuity and visual distortion. Structural optical coherence tomography biomarkers have shown potential for predicting visual outcomes following surgery.

objectiveTo evaluate the prognostic value of baseline structural optical coherence tomography biomarkers for visual outcomes following epiretinal membrane surgery. We will assess associations between individual biomarkers and postoperative visual acuity or changes in visual acuity at 6, 12, and 24 months after surgery.

methodsWe will systematically search MEDLINE, EMBASE, CENTRAL and Web of Science from inception. Eligible studies will include randomized trials and observational studies reporting the association between any baseline optical coherence tomography biomarkers and postoperative visual acuity in patients undergoing epiretinal membrane surgery. Two reviewers will independently and in duplicate perform screening, data extraction, and risk of bias assessment. Meta-analyses using the restricted maximum likelihood random-effects model will be conducted whenever possible. The certainty of evidence for each estimate will be assessed using the GRADE approach. EXPECTED OUTCOMES: This review will analyze time-specific association between baseline structural optical coherence tomography biomarkers and postoperative visual acuity and change in visual acuity from baseline at 6, 12, and 24 months after surgery, quality of life measured using any validated scale, and adverse events.

Indexed as

Epiretinal MembraneTomography, Optical CoherenceVisual AcuityBiomarkersHumansMeta-Analysis as TopicPrognosisSystematic Reviews as TopicBiomarkers

Identifiers

PMID41401159
PMCPMC12707667

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.