Evidence map›Paper›PMID 41401081›Full record

ArticleeLife2025

Immunoglobulin M regulates airway hyperresponsiveness independent of T helper 2 allergic inflammation.

Sabelo Hadebe, Anca Flavia Savulescu, Jermaine Khumalo, Katelyn Jones, Sandisiwe Mangali, Nontobeko Mthembu, Fungai Musaigwa, Welcome Maepa, Hlumani Ndlovu, Amkele Ngomti and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sabelo HadebeDivision of Immunology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.ORCID 0000-0002-6049-8395
Anca Flavia SavulescuDivision of Chemical, Systems & Synthetic Biology, Faculty of Health Sciences, Institute of Infectious Disease & Molecular Medicine, University of Cape Town, Cape Town, South Africa.ORCID 0000-0002-3428-0157
Jermaine KhumaloDivision of Immunology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Katelyn JonesDivision of Immunology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Sandisiwe MangaliDivision of Immunology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Nontobeko MthembuDivision of Immunology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Fungai MusaigwaDivision of Immunology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Welcome MaepaDivision of Chemical, Systems & Synthetic Biology, Faculty of Health Sciences, Institute of Infectious Disease & Molecular Medicine, University of Cape Town, Cape Town, South Africa.ORCID 0000-0003-2881-5167
Hlumani NdlovuDivision of Chemical, Systems & Synthetic Biology, Faculty of Health Sciences, Institute of Infectious Disease & Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Amkele NgomtiDivision of Immunology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Martyna ScibiorekDivision of Immunology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Javan OkendoDivision of Chemical, Systems & Synthetic Biology, Faculty of Health Sciences, Institute of Infectious Disease & Molecular Medicine, University of Cape Town, Cape Town, South Africa.ORCID 0000-0001-8218-5448
Frank BrombacherDivision of Immunology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

Funding

National Research Foundation CSUR 138072National Research Foundation MSc ScholarshipNational Research Foundation Research Chair initiative (SARChi)National Research Foundation Thuthuka 117721South African Medical Research Council PhD FellowshipSouth African Medical Research Council Self initiated grantUniversity of Cape Town ATAP FellowshipWellcome TrustWellcome Trust 203135Z/16/Z
6 · The paper itself

Abstract

Allergic asthma is a disease driven by T helper 2 (Th2) cells, eosinophilia, airway hyperresponsiveness (AHR), and IgE-secreting B cells. Asthma is largely controlled by corticosteroids and β

Indexed as

AsthmaImmunoglobulin MMicrofilament ProteinsRespiratory HypersensitivityAllergensAnimalsCell LineDisease Models, AnimalHumansLungMiceMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutMuscle ContractionMuscle, SmoothAllergensBAIAP2L1 protein, humanImmunoglobulin MIRTKS protein, mouseMicrofilament Proteinsairway hyperresponsivenessairway smooth muscleB cellsfluorescently labelled elastomeric contractible surfaceImmunoglobulin Mimmunologyinflammationmousesingle cell force cytometry

Identifiers

PMID41401081
PMCPMC12707823

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.