ArticleeLife2025
Lifestyles shape genome size and gene content in fungal pathogens.
Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed.
- Quantitative comparison of fungal genome assembly strategies using short and long reads from simulated and empirical sequencing data.Microbial genomics · 2026Article
- Lineage-Specific Gene Family Innovations Underpin the Pathogenicity of Woody-Plant Pathogens in Botryosphaeriaceae.Genome biology and evolution · 2026Article
- The dynamics of transposable element content in the genome of the human pathogen Histoplasma.Fungal genetics and biology : FG & B · 2026Article
- Pan-Mitogenome Construction, Intraspecific Variation, and Adaptive Evolution of the Plant Pathogenic FungusBiology · 2025Article
- Genomic Exploration of Climate-driven Evolution and Evolutionary Convergence in Forest Pathogens.Genome biology and evolution · 2025Article
- Characterization of the mitochondrial genomes forIMA fungus · 2025Article
- Whole genome regulatory effect ofmBio · 2024Article
- Comparative Genomics of Fungi in Nectriaceae Reveals Their Environmental Adaptation and Conservation Strategies.Journal of fungi (Basel, Switzerland) · 2024Article
- Article
- Unraveling the transcriptional features and gene expression networks of pathogenic and saprotrophicMicrobiology spectrum · 2024Article
- Independent Evolution Has Led to Distinct Genomic Signatures in Dutch Elm Disease-Causing Fungi and Other Vascular Wilts-Causing Fungal Pathogens.Journal of fungi (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fungi display a wide range of lifestyles and hosts. We still know little about the impact of lifestyles, including pathogenicity, on their genome architecture. Here, we combined and annotated 552 fungal genomes from the class Sordariomycetes and examined the association between 13 genomic and two lifestyle traits: pathogenicity and insect-association. We found that pathogens, on average, tend to have a larger number of protein-coding genes, including effectors and tRNA genes. In addition, the non-repetitive size of their genomes is larger than that of non-pathogenic species. However, this pattern is not consistent across all groups. Insect endoparasites and symbionts have smaller genome sizes and genes with longer exons; moreover, insect-vectored pathogens possess fewer genes compared to those not transmitted by insects. Our study shows that genes are the main contributors to genome size variation in Sordariomycetes and that pathogens can exhibit distinct genome architectures, depending on their host and vector interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.