ArticleCell reports2025
Cellular and immune adaptations at the maternal-fetal interface in bats.
Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Total Immunoglobulin G Variation Through the Phenological Cycle of Migrant and Resident Lesser Long-Nosed Bats (Leptonycteris yerbabuenae) in the Drylands of Mexico and Its Relationship With Bacterial Killing-Ability of Plasma.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2026Article
- Trimester-dependent vertical transmission of H5N1 influenza virus through placental and mammary routes impairs offspring development.Nature communications · 2026Article
- Leveraging organoid models to understand mechanisms of viral infections and immunity in bats.Disease models & mechanisms · 2026Review
- The significance of CEACAM60, a carcinoembryonic antigen (CEA) homolog, as a tumor antigen in the porcine cancer model.Frontiers in immunology · 2026Article
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11 authors.
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Abstract
Bats experience extreme physiological conditions rarely encountered by other mammals, including prolonged gestation relative to other small species, high metabolic demands, temperature fluctuations during flight, and continual microbial exposure. These traits make them a powerful model for understanding placental adaptation during pregnancy. Here, we define the cellular and molecular architecture of the Jamaican fruit bat (Artibeus jamaicensis) placenta using single-nucleus RNA sequencing and tissue-derived organoid models. This analysis reveals diverse trophoblast, stromal, and immune populations with bat-specific transcriptional programs, including fibroblasts with hybrid adventitial and neuronal signatures and macrophages expressing pregnancy-associated molecules typically restricted to trophoblasts. Comparative analyses with human and mouse placentas uncover both conserved and lineage-specific features. Functional assays demonstrate that bat trophoblast organoids maintain high basal antiviral gene expression but limited inducibility following viral stimulation, revealing a unique strategy of immune vigilance without inflammation at the maternal-fetal barrier that may underpin reproductive success under physiological extremes.
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