Evidence map›Paper›PMID 41401000›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Asymmetrical recognition and processing of double-strand breaks formed during DNA replication.

Matthew J Johnson, Michael T Kimble, Seoyeon Jeong, Aakanksha Sane, Lorraine S Symington

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Matthew J JohnsonDepartment of Biological Sciences, Columbia University, New York, NY 10027.ORCID 0000-0002-4312-5618
Michael T KimbleDepartment of Biological Sciences, Columbia University, New York, NY 10027.
Seoyeon JeongDepartment of Biological Sciences, Columbia University, New York, NY 10027.
Aakanksha SaneDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032.
Lorraine S SymingtonDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032.ORCID 0000-0002-1519-4800

Funding

Mechanism and regulation of DNA double-strand break repairR35GM126997 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Lorraine S Symington · 2018 to 2026
$5.9M
Genome and Epigenome Integrity In CancerT32CA265828 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Alberto Ciccia, Chao Lu · 2022 to 2026
$1.8M
NCI NIH HHS T32 CA265828NIGMS NIH HHS R35 GM126997
6 · The paper itself

Abstract

DNA end resection to generate 3' single-stranded DNA (ssDNA) overhangs is the first step in homology-directed mechanisms of double-strand break (DSB) repair. While end resection has been extensively studied in the repair of endonuclease-induced DSBs, little is known about how resection proceeds at DSBs generated during DNA replication. We previously established a system to generate replication-dependent double-ended DSBs at the sites of nicks induced by the Cas9

Indexed as

DNA Breaks, Double-StrandedDNA ReplicationSaccharomyces cerevisiaeDNA, FungalDNA RepairDNA, Single-StrandedEndodeoxyribonucleasesExodeoxyribonucleasesKu AutoantigenSaccharomyces cerevisiae ProteinsDNA, FungalDNA, Single-StrandedEndodeoxyribonucleasesExodeoxyribonucleasesKu AutoantigenMRE11 protein, S cerevisiaeSaccharomyces cerevisiae ProteinsDNA double-strand breakDNA replicationend resectionKuMre11

Identifiers

PMID41401000
PMCPMC12745752

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.