Evidence map›Paper›PMID 41400995›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

An abundant membrane protein in the NCAM superfamily is required for epithelial organization in sea anemone embryos.

Anna Postnikova, Julissa G Tello, Maristhela Alvarez, Grace Y Lee, Ilhan Ali, Christine M Field, Timothy J Mitchison, Katerina Ragkousi

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. An abundant membrane protein in the NCAM superfamily is required for epithelial organization in sea anemone embryos.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anna PostnikovaDepartment of Biology, Amherst College, Amherst, MA 01002.ORCID 0009-0005-2932-9365
Julissa G TelloDepartment of Biology, Amherst College, Amherst, MA 01002.ORCID 0009-0009-7866-7327
Maristhela AlvarezDepartment of Biology, Amherst College, Amherst, MA 01002.ORCID 0009-0008-4855-0518
Grace Y LeeDepartment of Biology, Amherst College, Amherst, MA 01002.
Ilhan AliDepartment of Biology, Amherst College, Amherst, MA 01002.ORCID 0009-0006-0112-9510
Christine M FieldDepartment of Systems Biology, Harvard Medical School, Boston, MA 02115.ORCID 0000-0002-6433-7804
Timothy J MitchisonDepartment of Systems Biology, Harvard Medical School, Boston, MA 02115.ORCID 0000-0001-7781-1897
Katerina RagkousiDepartment of Biology, Amherst College, Amherst, MA 01002.ORCID 0000-0001-9383-225X

Funding

Cell and Chemical Biology of MicrotubulesR35GM131753 · NIGMS · HARVARD MEDICAL SCHOOL · PI Timothy J Mitchison · 2019 to 2026
$6.4M
Cell cycle regulation of polarity proteins in proliferating epitheliaR15GM141979 · NIGMS · AMHERST COLLEGE · PI RAGKOUSI, KATERINA · 2021 to 2023
$553k
HHS | NIH | National Institute of General Medical Sciences (NIGMS) R15GM141979-01HHS | NIH | National Institute of General Medical Sciences (NIGMS) R35GM131753National Science Foundation (NSF) MRI-2117798NIGMS NIH HHS R15 GM141979NIGMS NIH HHS R35 GM131753
6 · The paper itself

Abstract

Assembly of cells into epithelial layers marks the early steps of tissue organization and embryonic development in most animals. Although several conserved proteins are known to be essential for epithelialization in bilaterians, it is unclear whether these are sufficient to drive epithelial organization in all metazoans. Using proteomics and knockdown approaches in embryos of the early-branching sea anemone

Indexed as

Embryo, NonmammalianNeural Cell Adhesion MoleculesSea AnemonesAnimalsEpitheliumGastrulationNeural Cell Adhesion MoleculesepitheliagastrulationNematostella vectensisNeural Cell Adhesion Moleculeproteomic

Identifiers

PMID41400995
PMCPMC12745706

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.