Evidence map›Paper›PMID 41400929›Full record

ArticleVirulence2026

Auranofin potentiates linezolid activity against MRSA by disrupting redox homeostasis and inhibiting SarA-mediated virulence and biofilm.

Jian-Guo Li, Wei-Cheng Zhong, Long-Gen Zhong, Chao-Yan Niu, Ting-Yin Lu, Chuan-Jian Zhang, Jian Sun, Xiao-Ping Liao, Yu-Feng Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virulence, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. The dual role of the microbiome in chronic wound management.Cell communication and signaling : CCS · 2026
    Review
  2. Anti-staphylococcal activity of the auranofin-analogous PEtFrontiers in cellular and infection microbiology · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jian-Guo LiState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Wei-Cheng ZhongState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Long-Gen ZhongState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Chao-Yan NiuState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Ting-Yin LuState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Chuan-Jian ZhangState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Jian SunState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.ORCID 0000-0002-4209-7555
Xiao-Ping LiaoState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.ORCID 0000-0002-4654-5837
Yu-Feng ZhouState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methicillin-resistant

Indexed as

AuranofinBacterial ProteinsLinezolidMethicillin-Resistant Staphylococcus aureusStaphylococcal InfectionsTrans-ActivatorsAnimalsAnti-Bacterial AgentsBiofilmsCell LineDisease Models, AnimalDNA-Binding ProteinsDrug Resistance, BacterialDrug SynergismDrug Therapy, CombinationGene Expression Regulation, BacterialAnti-Bacterial AgentsAuranofinBacterial ProteinsDNA-Binding ProteinsLinezolidReactive Oxygen SpeciesSarA protein, bacterialThioredoxin-Disulfide ReductaseTrans-ActivatorsVirulence FactorsauranofinbiofilmlinezolidMRSAredox imbalancevirulence

Identifiers

PMID41400929
PMCPMC12721097

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.