Evidence map›Paper›PMID 41400897›Full record

ArticleNeuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater2026

[Diagnostic challenges of Wernicke-Korsakoff syndrome: A case report].

Paula Hoppstock, Lea Sommer, Mathias Jachs, Clemens Dejaco, Gregor Kasprian, Radheshyam Stepponat, Armin Trojer, Sabine Weber, Stephan Listabarth, Daniel König

Abstract readCase ReportsEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Paula HoppstockKlinische Abteilung für Sozialpsychiatrie, Universitätsklinik für Psychiatrie und Psychotherapie, Medizinische Universität Wien, Währinger Gürtel 18-20, 1090, Wien, Österreich. paula.hoppstock@meduniwien.ac.at.ORCID http://orcid.org/0009-0003-2020-7906
Lea SommerKlinische Abteilung für Sozialpsychiatrie, Universitätsklinik für Psychiatrie und Psychotherapie, Medizinische Universität Wien, Währinger Gürtel 18-20, 1090, Wien, Österreich.
Mathias JachsKlinische Abteilung für Gastroenterologie und Hepatologie, Univ.-Klinik für Innere Medizin III, Medizinische Universität Wien, Wien, Österreich.
Clemens DejacoKlinische Abteilung für Gastroenterologie und Hepatologie, Univ.-Klinik für Innere Medizin III, Medizinische Universität Wien, Wien, Österreich.
Gregor KasprianComprehensive Center for Clinical Neurosciences and Mental Health (C3NMH), Medizinische Universität Wien, Wien, Österreich.
Radheshyam StepponatComprehensive Center for Clinical Neurosciences and Mental Health (C3NMH), Medizinische Universität Wien, Wien, Österreich.
Armin TrojerKlinische Abteilung für Sozialpsychiatrie, Universitätsklinik für Psychiatrie und Psychotherapie, Medizinische Universität Wien, Währinger Gürtel 18-20, 1090, Wien, Österreich.
Sabine WeberKlinische Abteilung für Sozialpsychiatrie, Universitätsklinik für Psychiatrie und Psychotherapie, Medizinische Universität Wien, Währinger Gürtel 18-20, 1090, Wien, Österreich.
Stephan ListabarthKlinische Abteilung für Sozialpsychiatrie, Universitätsklinik für Psychiatrie und Psychotherapie, Medizinische Universität Wien, Währinger Gürtel 18-20, 1090, Wien, Österreich.
Daniel KönigKlinische Abteilung für Sozialpsychiatrie, Universitätsklinik für Psychiatrie und Psychotherapie, Medizinische Universität Wien, Währinger Gürtel 18-20, 1090, Wien, Österreich.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Korsakoff syndrome (KS) presents an interdisciplinary challenge in diagnosis and care. The frequent lack of distinct clinical symptoms represents a diagnostic challenge and can complicate early diagnosis. This case report describes a 59-year-old patient who initially presented to internal medicine due to symptoms that appeared to be associated with pre-known cardiovascular and metabolic comorbidities. The initial suspected diagnosis of osmotic demyelination syndrome (formerly known as pontine myelinolysis), which can induce a clinical state very similar to KS, could only be ruled out by MRI evidence of atrophy of the mammillary bodies, confirming the diagnosis of KS. High-dose thiamine supplementation, neurorehabilitative measures, and support by a stable social environment, led to an improvement in cognitive performance. This case highlights the need for differential diagnostic efforts regarding KS and interdisciplinary awareness beyond neurological and psychiatric disciplines.

Indexed as

Korsakoff SyndromeAlcoholismAtrophyBrainCombined Modality TherapyDiagnosis, DifferentialHumansInterdisciplinary CommunicationIntersectoral CollaborationMagnetic Resonance ImagingMaleMiddle AgedMyelinolysis, Central PontineThiamineThiamine DeficiencyThiamineAlcohol use disorderMamillary body atrophyOsmotic demyelination syndromeThiamine deficiencyWernicke-Korsakoff syndrome

Identifiers

PMID41400897
PMCPMC13541783

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.