Evidence map›Paper›PMID 41400882›Full record

ReviewHormones (Athens, Greece)2026

Pineal gland senescence: an emerging ageing-related pathology?

Emma Short, Ramzi Ajjan, Thomas M Barber, Sunil Bhandari, Paul Chazot, Jennifer L Garrison, Anushka Goyal, Robert Huckstepp, Noordin Jamal, Venkateswarlu Kanamarlapudi and 7 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Hormones (Athens, Greece), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Emma ShortCardiff School of Technologies, Cardiff Metropolitan University, Cardiff, UK. eshort@cardiffmet.ac.uk.ORCID http://orcid.org/0000-0001-5050-589X
Ramzi AjjanLeeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.
Thomas M BarberWarwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism, University Hospitals Coventry and Warwickshire, Clifford Bridge Road, Coventry, UK.
Sunil BhandariDepartment of Renal Medicine, Hull University Teaching Hospitals NHS Trust, Hull, UK.
Paul ChazotDurham University, Durham, UK.
Jennifer L GarrisonCenter for Healthy Aging in Women, Buck Institute for Research on Aging, CA, Novato, USA.
Anushka GoyalBristol Medical School, Bristol, UK.
Robert HucksteppSchool of Life Sciences, University of Warwick, Coventry, UK.
Noordin JamalUniversity of East Anglia, Norwich, UK.
Venkateswarlu KanamarlapudiSwansea University Medical School, Swansea University, Swansea, UK.
Alpar LazarUniversity of East Anglia, Norwich, UK.
Thomas LeeDepartment of Cellular Pathology, Swansea Bay University Health Board, Swansea, UK.
Adriana A S TavaresCentre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.
Jeremy J TreeDirector of Advanced Diagnostics and Medical Technologies Research Institute, Swansea University, Swansea, UK.
Jack WellingtonLeeds Teaching Hospital NHS Foundation Trust, Leeds, UK.
Stuart Rg CalimportCardiff School of Technologies, Cardiff Metropolitan University, Cardiff, UK.
Barry BentleyCardiff School of Technologies, Cardiff Metropolitan University, Cardiff, UK.

Funding

Impetus Grant, Norn Group Impetus Grant, Norn Group
6 · The paper itself

Abstract

An ageing-related pathology has recently been described as one that develops and/or progresses with increasing chronological age, that is associated with, or contributes to, functional decline and that is evidenced by studies in humans. The pineal gland is a photo-neuroendocrine organ whose primary function is to produce and secrete melatonin in response to light-dark cycle environmental cues. The gland may undergo ageing-related structural and morphological changes, including calcification, gliosis, cyst formation, and reduced density of β-adrenergic receptors, which are hypothesised to reduce melatonin secretion. Pineal gland senescence describes the ageing-related decline in neuroendocrine function, with reduced secretion of melatonin, which may contribute to ageing-related sleep disorders and disruption of other circadian-driven physiological functions and may have secondary effects such as contributing to cognitive and mood disorders related to sleep disturbance.

Indexed as

AgingPineal GlandAnimalsCircadian RhythmHumansMelatoninSleep Wake DisordersMelatoninAgeingAgeing-related pathologyPineal glandPineal gland senescenceSenescence

Identifiers

PMID41400882
PMCPMC13013126

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.