ArticleAnnals of nuclear medicine2026
Prognostic value of integrated FDG PET/CT avidity and CT morphologic subtypes in invasive mucinous adenocarcinoma of the lung.
Article in Annals of nuclear medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Hybrid Deep Learning-Machine Learning Fusion of Clinical, Radiomic and Deep Learning Features for Preoperative Differentiation of Solitary Pulmonary Mucinous Adenocarcinoma.Diagnostics (Basel, Switzerland) · 2026Article
- Prediction of microinvasive spread in stage T1 non-small cell lung cancer based on a preoperative tumor margin CT radiomics model.Journal of thoracic disease · 2026Article
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5 authors.
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Abstract
purposeAssessing the prognostic value of
methodsThis dual-centre retrospective study included patients diagnosed with pulmonary IMA between January 2010 and August 2020. The patients were categorized into three groups based on CT morphology: solitary pulmonary nodule (SPN), pneumonic, and multifocal types. FDG avidity of the primary lesion was visually assessed using the mediastinal blood pool as a reference. Disease-free survival (DFS) was analysed in patients who underwent curative surgical resection.
resultsA total of 139 patients (mean age: 69.1 years) were included. Most patients had SPN-type tumors (63.3%), of which 60.2% were FDG-avid, whereas all patients with pneumonic-type (18.0%) were FDG-avid. DFS analysis was performed in 78 surgically treated patients, with recurrence observed in 18 cases. Univariate analysis identified T stage, nodal involvement, CT imaging phenotype, visceral pleural invasion (VPI), and FDG avidity as significant prognostic factors. In a multivariate analysis, CT imaging phenotype, VPI, and FDG avidity remained independent prognostic factors. When patients were stratified into three groups-non-FDG-avid SPN-type, FDG-avid SPN-type, and pneumonic-type-Kaplan-Meier analysis demonstrated a significantly longer DFS in non-FDG-avid SPN-type patients than in the other groups. The median DFS was not reached for non-FDG-avid or FDG-avid SPN-type groups, whereas it was 21.0 months for patients in the pneumonic-type group.
conclusionUtilization of FDG PET/CT, particularly when combined with CT findings, may enhance the prognostic stratification of patients with curatively resected IMA of the lung, as visual FDG avidity is associated with worse prognosis.
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