ArticleGeneral thoracic and cardiovascular surgery2026
Prognostic impact of lung diffusion capacity in patients with early-stage lung cancer achieving 5-year postoperative recurrence-free survival: propensity score matching analysis.
Article in General thoracic and cardiovascular surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Abstract
objectiveLong-term prognosis in patients with early-stage non-small cell lung cancer (NSCLC) achieving 5-year postoperative recurrence-free survival (RFS) has been examined in previous studies. However, no prognostic factors have been identified that contribute to the management of long-term NSCLC survivors. Therefore, this study aims to investigate the factors affecting long-term prognosis, with a focus on the percent predicted diffusing capacity of the lung for carbon monoxide divided by alveolar volume (%DLCO/VA).
methodsA retrospective analysis was performed on 642 patients with stage I NSCLC who achieved a 5-year postoperative RFS. Patients were categorized based on the value of %DLCO/VA. We assessed the impact of low %DLCO/VA on long-term prognosis and analyzed cause of death using propensity score matching.
resultsSixty-seven (10.4%) patients died after achieving 5-year postoperative RFS, and the 5–10-year overall survival (OS) rate was 85.0%. After propensity score matching, there are 186 patients in the normal %DLCO/VA group and 93 patients in the low %DLCO/VA group. The 5–10year OS rate was significantly better in normal %DLCO/VA group than low %DLCO/VA group (81.5% vs. 64.0%; HR: 1.86). Moreover, among causes of 5–10year death, pneumonia-related deaths were significantly more frequent in the low %DLCO/VA group after propensity score matching (p = 0.04).
conclusionsOur findings suggest that low %DLCO/VA value is a significant factor in long-term prognosis even after achieving 5-year postoperative RFS, and significantly increases the incidence of pneumonia-related deaths. Postoperative management to prevent pneumonia is essential for long-term survival of patients with low %DLCO/VA value.
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