Trial reportJournal of assisted reproduction and genetics2026
Nonlinear association of serum luteinizing hormone on hCG trigger day with cumulative live birth in IVF cycles: secondary analysis of a randomized clinical trial.
Trial report in Journal of assisted reproduction and genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03118141 (Cumulative Live Birth Rate With eSET After In-vitro Fertilization With Preim-plantation Genetic Screening by Next Generation Sequencing Versus Conventional In-vitro Fertilization), which is not on this map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cumulative Live Birth Rate With eSET After In-vitro Fertilization With Preim-plantation Genetic Screening by Next Generation Sequencing Versus Conventional In-vitro Fertilization: A Pragmatic Randomized Controlled Clinical Trial
Who cites it
1 citing paper in PubMed.
- Associations Between Miscarriage and Postpartum Depression, Perceived Social Support, and Medical Needs in Pregnant Women: A Single-Center Retrospective Study.Actas espanolas de psiquiatria · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
purposeTo investigate the impact of serum luteinizing hormone (LH) levels on the day of human chorionic gonadotropin (hCG) trigger on cumulative live birth in women undergoing in vitro fertilization (IVF) cycles.
methodsThis was a secondary analysis of a multicenter randomized controlled trial (NCT03118141). A total of 1212 infertile women undergoing their first IVF cycle with a good prognosis for live birth were included. Participants were stratified into three groups according to tertiles of serum LH levels on the hCG trigger day (hLH): low-hLH (< 1.28 IU/L), medium-hLH (1.28-3.26 IU/L), and high-hLH (> 3.26 IU/L). Logistic regression and restricted cubic spline models were used to evaluate associations, adjusting for maternal age, body mass index, and baseline hormones.
resultsCompared to the medium-hLH group, the low-hLH group exhibited significantly lower cumulative clinical pregnancy and live birth rates, along with a higher biochemical pregnancy loss rate (P < 0.05). The high-hLH group demonstrated a reduced cumulative live birth rate, while other pregnancy outcomes were comparable to the medium-hLH group. A restricted cubic spline analysis revealed a significant nonlinear, inverted U-shaped relationship between serum hLH levels and cumulative live birth rates, with the optimal threshold around 1.95 IU/L. Stratified analysis indicated that the impact of hLH levels was more pronounced in women undergoing GnRH antagonist protocols.
conclusionsSerum hLH levels exhibit a nonlinear association with cumulative live birth rates in IVF cycles, highlighting 1.95 IU/L as a potential threshold. Individualized adjustment of hLH levels may improve pregnancy outcomes, especially in GnRH antagonist protocols.
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