Evidence map›Paper›PMID 41400774›Full record

ArticleDigestive diseases and sciences2026

Stable Nationwide Sepsis-Related Mortality Does Not Extend to Individuals with Alcohol-Associated Liver Disease.

Pojsakorn Danpanichkul, Kwanjit Duangsonk, Claire S Faulkner, Supapitch Sirimangklanurak, Tulaton Sodsri, Natchaya Polpichai, Shu-Yen Chan, Yanfang Pang, Omar Y Mousa, Donghee Kim and 2 more

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Article in Digestive diseases and sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Pojsakorn Danpanichkul *Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA. pojsakorndan@gmail.com.
Kwanjit Duangsonk *Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Claire S FaulknerBoston University Medical Center, Boston, MA, USA.
Supapitch SirimangklanurakFaculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Tulaton SodsriDepartment of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA.
Natchaya PolpichaiDivision of Gastroenterology and Hepatology, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Shu-Yen ChanDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Yanfang PangAffiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi, China.
Omar Y MousaDepartment of Transplantation, Mayo Clinic, Jacksonville, FL, USA.
Donghee KimDivision of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA, USA.
Suthat LiangpunsakulDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Karn WijarnpreechaDivision of Gastroenterology and Hepatology, Department of Medicine, University of Arizona College of Medicine, Phoenix, AZ, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsSepsis remains highly fatal despite national improvements from the Surviving Sepsis Campaign; furthermore, its effects on patients with alcohol-associated liver disease (ALD) are not well understood.

methodsUsing the Centers for Disease Control and Prevention Wide-raning Online Data for Epidemiological Research (CDC WONDER) death certificate data from 2011 to 2020, we identified deaths with sepsis as the underlying cause and ALD as a contributing cause. Age-adjusted mortality rates (AAMRs) and annual percent change (APC) were calculated overall and by sex, race/ethnicity, region, and urbanization level.

resultsBetween 2011 and 2020, a total of 2357 sepsis-related deaths occurred among ALD patients in the United States (U.S.) While sepsis-related mortality in the overall population remained stable (APC: - 0.88%, 95% CI [confidence interval] - 2.00 to 0.25%), it increased significantly in ALD patients (APC: 8.86%, 95% CI 5.07 to 12.79%). Mortality increased in both sexes, with mortality in females (APC: 9.68%, 95% CI 4.58 to 15.03%) increasing more pronouncedly than in males (APC: 7.79%, 95% CI 4.13 to 11.58%). AAMRs from sepsis-related mortality in ALD individuals increased in the Midwest (APC: 10.77%, 95% CI 4.58 to 17.33%), South (APC: 6.78%, 95% CI 0.26 to 13.73%), and West (APC: 7.35%, 95% CI 3.16 to 11.71%) census areas while remaining stable in the Northeast census area.

conclusionDespite sepsis-related mortality in the U.S. population remaining stable, rates among ALD patients have increased over the past decade. These patterns underscore disparities and the need for targeted interventions such as enhancing early sepsis detection, expanding specialty access, and strengthening alcohol use treatment pathways.

Indexed as

Liver Diseases, AlcoholicSepsisAdultAgedAged, 80 and overCause of DeathFemaleHumansMaleMiddle AgedRisk FactorsUnited StatesAlcohol-associated liver diseaseInfectionInfectious diseasePublic healthSepticemia

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PMID41400774

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.